Brief Information of the Compound and Protein
Compound Name
 Compound Info 
3-(3-fluoro-4-{[2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxy}phenyl)-1-(2-phenylacetyl)thiourea
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 PubChem ID
CID: 24901704
SID: 125313607
Canonical SMILES
Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)c2s1
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Compound Formula C26H20FN5O2S2
Compound Structure
Protein Name
 Protein Info 
Hepatocyte growth factor receptor
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase Met family
Uniprot ID
P08581
Gene Name
MET
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000068 A-549
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 400 nM
   TI
   LI
   LO
   TS
CL000023 BTI-Tn-5B1-4
 Cell Line Info 
Trichoplusia ni (Cabbage looper)  1
1
IC50 = 37 nM
   TI
   LI
   LO
   TS
CL000119 DU145
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 80 nM
   TI
   LI
   LO
   TS
CL000025 HEK-293T
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 50 nM
   TI
   LI
   LO
   TS
CL000013 Sf9
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  2
1
IC50 = 29 nM
   TI
   LI
   LO
   TS
2
IC50 = 37 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 12 nM
2 IC50 = 37 nM