Brief Information of the Compound and Protein
Compound Name
(-)-(etorphine)
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PubChem ID
CID: 5288826
SID: 14897787
Canonical SMILES
CN1CC[C@@]23[C@H]4Oc5c2c(C[C@@H]1[C@@H]3C=C[C@@H]4O)ccc5O
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Compound Formula C17H19NO3
Compound Structure
Protein Name
Kappa-type opioid receptor
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Short peptide receptor (family A GPCR)
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Opioid receptor
Uniprot ID
P41145
Gene Name
OPRK1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  12
1
EC50 = 484 nM
   TI
   LI
   LO
   TS
2
ED50 = 1140 nM
   TI
   LI
   LO
   TS
3
Ki = 6.9 nM
   TI
   LI
   LO
   TS
4
Ki = 24 nM
   TI
   LI
   LO
   TS
5
Ki = 36.8 nM
   TI
   LI
   LO
   TS
6
Ki = 46.9 nM
   TI
   LI
   LO
   TS
7
Ki = 60.9 nM
   TI
   LI
   LO
   TS
8
Ki = 61 nM
   TI
   LI
   LO
   TS
9
Ki = 65.5 nM
   TI
   LI
   LO
   TS
10
Ki = 113 nM
   TI
   LI
   LO
   TS
11
Ki = 260 nM
   TI
   LI
   LO
   TS
12
Ki = 299 nM
   TI
   LI
   LO
   TS
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  1
1
EC50 = 330 nM
   TI
   LI
   LO
   TS
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 1705.1 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 33 nM
2 Ki = 33.7 nM
3 Ki = 46.9 nM
4 Ki = 52.14 nM
5 Ki = 64 nM
6 Ki = 86 nM
7 Ki = 120 nM
8 Ki = 260 nM
9 Ki = 1900 nM