Brief Information of the Compound and Protein
Compound Name
1-methyl-5-[2'-oxospiro[cyclohexane-1,3'-(2',3'-dihydro-1'H-indole)]-5-yl]-1H-2-pyrrolecarbonitrile
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PubChem ID
CID: 21986251
SID: 49840274
Canonical SMILES
Cn1c(ccc1-c1ccc2NC(=O)C3(CCCCC3)c2c1)C#N
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Compound Formula C19H19N3O
Compound Structure
Protein Name
Progesterone receptor
Protein Classification
Transcription factor
>
Nuclear receptor
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Nuclear hormone receptor subfamily 3
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Nuclear hormone receptor subfamily 3 group C
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Nuclear hormone receptor subfamily 3 group C member 3
Uniprot ID
P06401
Gene Name
PGR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000078 T-47D Homo sapiens (Human)  4
1
EC50 = 2.3 nM
   TI
   LI
   LO
   TS
2
EC50 = 2.8 nM
   TI
   LI
   LO
   TS
3
IC50 = 3.3 nM
   TI
   LI
   LO
   TS
4
IC50 > 3000 nM
   TI
   LI
   LO
   TS