Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(4R)-4-[(1S,2S,5R,7S,9R,10R,11S,14R,15R)-5,9-dihydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-14-yl]pentanoic acid
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 PubChem ID
CID: 10133
SID: 14780857
Canonical SMILES
C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
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Compound Formula C24H40O4
Compound Structure
Protein Name
 Protein Info 
Bile acid receptor
Protein Classification
Transcription factor
>
Nuclear receptor
>
Nuclear hormone receptor subfamily 1
>
Nuclear hormone receptor subfamily 1 group H
>
Nuclear hormone receptor subfamily 1 group H member 4
Uniprot ID
Q96RI1
Gene Name
NR1H4
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000109 COS-1
 Cell Line Info 
Chlorocebus aethiops (Green monkey)  1
1
EC50 = 13000 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 27000 nM
   TI
   LI
   LO
   TS
CL000017 HeLa
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 18000 nM
   TI
   LI
   LO
   TS
CL000063 Hep-G2
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 20000 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 EC50 = 3400 nM
2 EC50 = 3500 nM
3 EC50 = 8000 nM
4 EC50 = 8660 nM
5 EC50 = 9000 nM
6 EC50 = 10000 nM
7 EC50 = 13000 nM
8 EC50 = 15000 nM
9 EC50 = 18000 nM
10 EC50 = 21000 nM
11 EC50 = 30000 nM