Brief Information of the Compound and Protein
Compound Name
 Compound Info 
1-(3-chlorophenyl)piperazine
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 PubChem ID
CID: 1355
SID: 15487730
Canonical SMILES
Clc1cccc(c1)N1CCNCC1
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Compound Formula C10H13ClN2
Compound Structure
Protein Name
 Protein Info 
5-hydroxytryptamine receptor 2B
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Serotonin receptor
Uniprot ID
P41595
Gene Name
HTR2B
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
EC50 > 1000 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  3
1
EC50 = 39.81 nM
   TI
   LI
   LO
   TS
2
EC50 = 287 nM
   TI
   LI
   LO
   TS
3
Ki = 10 nM
   TI
   LI
   LO
   TS
CL000065 HEK293-EBNA
 Cell Line Info 
Homo sapiens (Human)  2
1
EC50 = 287 nM
   TI
   LI
   LO
   TS
2
Ki = 24 nM
   TI
   LI
   LO
   TS
CL000035 NIH 3T3
 Cell Line Info 
Mus musculus (Mouse)  1
1
EC50 = 125 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 32 nM