Brief Information of the Compound and Protein
Compound Name
N-[(2R)-1'-methyl-2',4'-dioxospiro[1,3-dihydroindene-2,5'-imidazolidine]-5-yl]-2-[2-oxo-3-(oxolan-3-yl)benzimidazol-1-yl]acetamide
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PubChem ID
CID: 44420240
Canonical SMILES
CN1C(=O)NC(=O)[C@]11Cc2ccc(NC(=O)Cn3c4ccccc4n(C4CCOC4)c3=O)cc2C1
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Compound Formula C25H25N5O5
Compound Structure
Protein Name
Calcitonin gene-related peptide type 1 receptor
Protein Classification
Membrane receptor
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Family B G protein-coupled receptor
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Peptide receptor (family B GPCR)
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Calcitonin-like receptor
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Calcitonin gene-related peptide receptor
Uniprot ID
Q16602
Gene Name
CALCRL
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  3
1
IC50 = 61 nM
   TI
   LI
   LO
   TS
2
IC50 = 170 nM
   TI
   LI
   LO
   TS
3
Ki = 20 nM
   TI
   LI
   LO
   TS
CL000748 NAL1A clone C4E10 Mus musculus (Mouse)  1
1
IC50 = 61 nM
   TI
   LI
   LO
   TS