Brief Information of the Compound and Protein
Compound Name
Benzo[b]thiophen-3-yl-[(4aR,5S)-1-(4-fluoro-phenyl)-4a-methyl-4,4a,5,6,7,8-hexahydro-1H-benzo[f]indazol-5-yl]-methanol
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PubChem ID
CID: 44394927
Canonical SMILES
C[C@]12Cc3cnn(c3C=C1CCC[C@@H]2C(O)c1csc2ccccc12)-c1ccc(F)cc1
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Compound Formula C27H25FN2OS
Compound Structure
Protein Name
Glucocorticoid receptor
Protein Classification
Transcription factor
>
Nuclear receptor
>
Nuclear hormone receptor subfamily 3
>
Nuclear hormone receptor subfamily 3 group C
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Nuclear hormone receptor subfamily 3 group C member 1
Uniprot ID
P06536
Gene Name
NR3C1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000043 U2OS Homo sapiens (Human)  4
1
EC50 = 1.8 nM
   TI
   LI
   LO
   TS
2
EC50 = 20 nM
   TI
   LI
   LO
   TS
3
EC50 = 22 nM
   TI
   LI
   LO
   TS
4
IC50 = 1.8 nM
   TI
   LI
   LO
   TS