Brief Information of the Compound and Protein
Compound Name
8-[1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-pyrrolidin-3-yloxy]-quinolin-2-ylamine
    Show/Hide
PubChem ID
CID: 10000146
SID: 14979822
Canonical SMILES
Nc1ccc2cccc(OC3CCN(C3)c3ccc4OC(F)(F)Oc4c3)c2n1
    Show/Hide
Compound Formula C20H17F2N3O3
Compound Structure
Protein Name
Melanin-concentrating hormone receptor 1
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Short peptide receptor (family A GPCR)
>
MCH receptor
Uniprot ID
Q99705
Gene Name
MCHR1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000863 I3.4.2 Homo sapiens (Human)  1
1
IC50 = 0.9 nM
   TI
   LI
   LO
   TS
CL000016 IMR-32 Homo sapiens (Human)  1
1
IC50 = 22.4 nM
   TI
   LI
   LO
   TS