Brief Information of the Compound and Protein
Compound Name
 Compound Info 
6-[4-(4-Benzylphthalazin-1-yl)[1,4]diazepan-1-yl]nicotinonitrile
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 PubChem ID
CID: 25067132
SID: 56404013
Canonical SMILES
N#Cc1ccc(nc1)N1CCCN(CC1)c1nnc(Cc2ccccc2)c2ccccc12
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Compound Formula C26H24N6
Compound Structure
Protein Name
 Protein Info 
Protein smoothened
Protein Classification
Membrane receptor
>
Frizzled family G protein-coupled receptor
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Smoothened receptor (frizzled family GPCR)
Uniprot ID
P56726
Gene Name
SMO
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
IC50 = 153 nM
   TI
   LI
   LO
   TS
CL000633 TM3
 Cell Line Info 
Mus musculus (Mouse)  2
1
IC50 = 210 nM
   TI
   LI
   LO
   TS
2
IC50 = 1632 nM
   TI
   LI
   LO
   TS