Brief Information of the Compound and Protein
Compound Name
 Compound Info 
1-[6-[4-(4-benzylphthalazin-1-yl)piperazin-1-yl]pyridin-3-yl]-N,N-dimethylmethanamine
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 PubChem ID
CID: 44186312
SID: 85181703
Canonical SMILES
CN(C)Cc1ccc(nc1)N1CCN(CC1)c1nnc(Cc2ccccc2)c2ccccc12
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Compound Formula C27H30N6
Compound Structure
Protein Name
 Protein Info 
Protein smoothened
Protein Classification
Membrane receptor
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Frizzled family G protein-coupled receptor
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Smoothened receptor (frizzled family GPCR)
Uniprot ID
P56726
Gene Name
SMO
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
IC50 = 287 nM
   TI
   LI
   LO
   TS
CL000633 TM3
 Cell Line Info 
Mus musculus (Mouse)  2
1
IC50 = 14 nM
   TI
   LI
   LO
   TS
2
IC50 = 246 nM
   TI
   LI
   LO
   TS