Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(4-chlorophenyl)-[4-(4-pyridylmethyl)phthalazin-1-yl]amine
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 PubChem ID
CID: 151194
SID: 14827532
Canonical SMILES
Clc1ccc(Nc2nnc(Cc3ccncc3)c3ccccc23)cc1
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Compound Formula C20H15ClN4
Compound Structure
Protein Name
 Protein Info 
Vascular endothelial growth factor receptor 2
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase VEGFR family
Uniprot ID
P35968
Gene Name
KDR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
IC50 = 16 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  2
1
IC50 < 15 nM
   TI
   LI
   LO
   TS
2
IC50 = 21 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 10 nM
2 IC50 = 20 nM
3 IC50 = 37 nM
4 IC50 = 42 nM
5 IC50 = 43 nM
6 IC50 = 54 nM
7 IC50 = 63 nM
8 IC50 < 100 nM
9 IC50 = 138 nM
10 IC50 = 140 nM
11 IC50 = 160 nM
12 IC50 = 180 nM
13 IC50 = 198.3 nM
14 IC50 = 6308.1 nM
15 IC50 = 6754 nM
16 Kd = 62 nM
17 Kd = 70 nM