Brief Information of the Compound and Protein
Compound Name
 Compound Info 
N-methyl-2-phenyl-N-[(5R,7S,8S)-7-(pyrrolidin-1-yl)-1-oxaspiro[4.5]decan-8-yl]acetamide
    Show/Hide
 PubChem ID
CID: 105104
SID: 50093889
Canonical SMILES
CN([C@H]1CC[C@@]2(CCCO2)C[C@@H]1N1CCCC1)C(=O)Cc1ccccc1
    Show/Hide
Compound Formula C22H32N2O2
Compound Structure
Protein Name
 Protein Info 
Mu-type opioid receptor
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Short peptide receptor (family A GPCR)
>
Opioid receptor
Uniprot ID
P35372
Gene Name
OPRM1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  5
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
2
Ki = 1145 nM
   TI
   LI
   LO
   TS
3
Ki = 2370 nM
   TI
   LI
   LO
   TS
4
Ki > 10000 nM
   TI
   LI
   LO
   TS
5
Ki > 2000 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 250 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 248 nM
2 Ki > 1000 nM