Brief Information of the Compound and Protein
Compound Name
4-(2-methyl-1,2-dihydrospiro[3,1-benzoxazine-4,1'-cyclohexan]-6-yl)thiophene-2-carbonitrile
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PubChem ID
CID: 23435613
Canonical SMILES
CC1Nc2ccc(cc2C2(CCCCC2)O1)-c1csc(c1)C#N
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Compound Formula C19H20N2OS
Compound Structure
Protein Name
Progesterone receptor
Protein Classification
Transcription factor
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Nuclear receptor
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Nuclear hormone receptor subfamily 3
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Nuclear hormone receptor subfamily 3 group C
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Nuclear hormone receptor subfamily 3 group C member 3
Uniprot ID
P06401
Gene Name
PGR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000078 T-47D Homo sapiens (Human)  2
1
EC50 = 3.5 nM
   TI
   LI
   LO
   TS
2
IC50 = 12 nM
   TI
   LI
   LO
   TS