Brief Information of the Compound and Protein
Compound Name
 Compound Info 
4-[3-(4-tert-Butyl-benzenesulfonylamino)-4-(3-methoxy-phenylsulfanyl)-isoxazol-5-yl]-butyric acid methyl ester
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 PubChem ID
CID: 44298330
Canonical SMILES
COC(=O)CCCc1onc(NS(=O)(=O)c2ccc(cc2)C(C)(C)C)c1Sc1cccc(OC)c1
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Compound Formula C25H30N2O6S2
Compound Structure
Protein Name
 Protein Info 
Endothelin receptor type B
Protein Classification
Membrane receptor
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Family A G protein-coupled receptor
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Peptide receptor (family A GPCR)
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Short peptide receptor (family A GPCR)
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Endothelin receptor
Uniprot ID
P35463
Gene Name
EDNRB
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000053 COS-7
 Cell Line Info 
Chlorocebus aethiops (Green monkey)  1
1
IC50 = 310 nM
   TI
   LI
   LO
   TS