Brief Information of the Compound and Protein
Compound Name
 Compound Info 
8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-azaspiro[4.5]decane-7,9-dione
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 PubChem ID
CID: 2419
SID: 14878226
Canonical SMILES
COc1ccccc1N1CCN(CCN2C(=O)CC3(CCCC3)CC2=O)CC1
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Compound Formula C22H31N3O3
Compound Structure
Protein Name
 Protein Info 
Alpha-1A adrenergic receptor
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Adrenergic receptor
Uniprot ID
P35348
Gene Name
ADRA1A
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  4
1
Kd = 380.19 nM
   TI
   LI
   LO
   TS
2
Ki = 380.19 nM
   TI
   LI
   LO
   TS
3
Ki = 389.05 nM
   TI
   LI
   LO
   TS
4
Ki = 436.52 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 130 nM
2 Ki = 251 nM
3 Ki = 290 nM
4 Ki = 294 nM
5 Ki = 380.19 nM