Brief Information of the Compound and Protein
Compound Name
 Compound Info 
[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(furan-2-yl)methanone
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 PubChem ID
CID: 4893
SID: 14804776
Canonical SMILES
COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)c1ccco1
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Compound Formula C19H21N5O4
Compound Structure
Protein Name
 Protein Info 
Alpha-1A adrenergic receptor
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Adrenergic receptor
Uniprot ID
P35348
Gene Name
ADRA1A
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  3
1
Ki = 0.04 nM
   TI
   LI
   LO
   TS
2
Ki = 0.58 nM
   TI
   LI
   LO
   TS
3
Ki = 0.5888 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 0.1995 nM
2 Ki = 0.27 nM
3 Ki = 0.39 nM
4 Ki = 0.51 nM
5 Ki = 0.58 nM
6 Ki = 0.61 nM