Brief Information of the Compound and Protein
Compound Name
 Compound Info 
2-(furan-2-yl)-7-phenethyl-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine
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 PubChem ID
CID: 176408
SID: 14900558
Canonical SMILES
Nc1nc2n(CCc3ccccc3)ncc2c2nc(nn12)-c1ccco1
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Compound Formula C18H15N7O
Compound Structure
Protein Name
 Protein Info 
Adenosine receptor A2a
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
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Nucleotide-like receptor (family A GPCR)
>
Adenosine receptor
Uniprot ID
P29274
Gene Name
ADORA2A
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
Ki = 1.1 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  6
1
Activity = 0.25 nM
   TI
   LI
   LO
   TS
2
Activity = 0.55 nM
   TI
   LI
   LO
   TS
3
IC50 = 40 nM
   TI
   LI
   LO
   TS
4
Ki = 1.1 nM
   TI
   LI
   LO
   TS
5
Ki = 1.23 nM
   TI
   LI
   LO
   TS
6
Ki = 4.3 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Kd = 1.973 nM
2 Kd = 3.34 nM
3 Kd = 16.8 nM
4 Ki = 0.6 nM
5 Ki = 1.1 nM
6 Ki = 2.3 nM