Brief Information of the Compound and Protein
Compound Name
 Compound Info 
9-Chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c]quinazolin-5-ylamine
    Show/Hide
 PubChem ID
CID: 2690
SID: 15071946
Canonical SMILES
Nc1nc2ccc(Cl)cc2c2nc(nn12)-c1ccco1
    Show/Hide
Compound Formula C13H8ClN5O
Compound Structure
Protein Name
 Protein Info 
Adenosine receptor A2b
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Nucleotide-like receptor (family A GPCR)
>
Adenosine receptor
Uniprot ID
P29275
Gene Name
ADORA2B
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  4
1
IC50 = 60.7 nM
   TI
   LI
   LO
   TS
2
IC50 = 1200 nM
   TI
   LI
   LO
   TS
3
Ki = 23 nM
   TI
   LI
   LO
   TS
4
Ki = 30 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  3
1
Ki = 9.8 nM
   TI
   LI
   LO
   TS
2
Ki = 16.4 nM
   TI
   LI
   LO
   TS
3
Ki = 34.2 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Kd = 10 nM
2 Ki = 44 nM