Brief Information of the Compound and Protein
Compound Name
2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2)
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PubChem ID
CID: 2803
SID: 14822899
Canonical SMILES
Clc1cccc(Cl)c1N=C1NCCN1
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Compound Formula C9H9Cl2N3
Compound Structure
Protein Name
Alpha-2C adrenergic receptor
Protein Classification
Membrane receptor
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Family A G protein-coupled receptor
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Small molecule receptor (family A GPCR)
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Monoamine receptor
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Adrenergic receptor
Uniprot ID
P18825
Gene Name
ADRA2C
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  3
1
EC50 = 57.54 nM
   TI
   LI
   LO
   TS
2
Ki = 9.333 nM
   TI
   LI
   LO
   TS
3
Ki = 30 nM
   TI
   LI
   LO
   TS
CL000028 PC-12 Homo sapiens (Human)  1
1
EC50 = 56 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 30 nM
2 Ki = 56.23 nM
3 Ki = 160 nM