Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

(S)-(-)-N-(R-ethylbenzyl)-3-hydroxy-2-phenylquinoline-4-carboxamide

Show/Hide

PubChem ID

CID: 5311424

SID: 57304378

Canonical SMILES	CC[C@H](NC(=O)c1c(O)c(nc2ccccc12)-c1ccccc1)c1ccccc1 Show/Hide
Compound Formula	C25H22N2O2

Compound Structure

Protein Name

Protein Info

Neuromedin-K receptor

Protein Classification

Membrane receptor

Family A G protein-coupled receptor

Peptide receptor (family A GPCR)

Short peptide receptor (family A GPCR)

Neurokinin receptor

Uniprot ID

P29371

Gene Name

TACR3

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	5
1	IC50 = 2.4 nM	TI LI LO TS
2	IC50 = 8.4 nM	TI LI LO TS
3	Ki = 1 nM	TI LI LO TS
4	Ki = 7.943 nM	TI LI LO TS
5	Ki = 254 nM	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	13
1	IC50 = 6.1 nM	TI LI LO TS
2	IC50 = 16.6 nM	TI LI LO TS
3	Kd = 2.344 nM	TI LI LO TS
4	Kd = 2.884 nM	TI LI LO TS
5	Kd = 5.754 nM	TI LI LO TS
6	Kd = 229.09 nM	TI LI LO TS
7	Ki = 1.7 nM	TI LI LO TS
8	Ki = 3 nM	TI LI LO TS
9	Ki = 3.6 nM	TI LI LO TS
10	Ki = 3.7 nM	TI LI LO TS
11	Ki = 10.6 nM	TI LI LO TS
12	Ki = 37.2 nM	TI LI LO TS
13	Ki = 122 nM	TI LI LO TS

Biochemical Assays

1	Ki = 7.4 nM