General Information of the Protein
Protein ID
PT07606
Protein Name
Relaxin receptor 1
Secondarily
Protein Name
Leucine-rich repeat-containing G-protein coupled receptor 7
Relaxin family peptide receptor 1
Gene Name
RXFP1
Secondarily
Gene Name
Lgr7
Sequence
MTSGPFFFCVFIIGRYFTLGNAQDVSCPLGSFPCGNISKCLPQLLHCNGVDDCGNQADEDNCGDNNGWSLQLDKYFANYYKLTSTNSIEAETSECLVGSVPMHCLCRDLELDCDEANLRAVPSVSSNVTVMSLQWNFIRTLPPNSFRKYHDLQKLCLQNNKIRSVSVSAFRGLHSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPLTFYGLNSLILLVLMNNALTRLPDKPLCQHMPRLHWLDFEGNRIHNLRNLTFISCNNLTVLVMRKNKINHLNEHAFTHLQKLDELDLGSNKIENLPPNIFKDLKELSQLNISYNPIQKIEVNQFDYLAKLKSLSLEGIEISNIQQRMFRPLINLSHIYFKKFQYCGYAPHVRSCKPNTDGISSLENLLASIIQRVFVWVVSAITCFGNIFVICMRPYIRSENKLHAMSIMSLCCADCLMGVYLFVIGAFDLKFRGEYRKHAQPWMESVHCQFMGSLAVLSTEVSVLLLTFLTLEKYICIVYPFRCLRPRKCRTVAVLIFIWITGFIVAFAPLGNKEFFKNYYGTNGVCFPLHSEDTGSTGAQIYSVVIFLGINLVAFIIIVFSYGSMFYSVHQSTITATEIQKQVKKEMILAKRFFFIVFTDALCWIPIFILKFLSLIRVEIPDTITSWVVIFILPINSALNPIIYTLTTRPFKEMIHQLWYNYRQRRSVDRKGTQKAYTPSFIWVEMWPLQEMSTEFMKPDAFTDPCDLSLVSRSSRLNSYS
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Organism
Rattus norvegicus, Rat
Protein Classification
Unclassified protein
Function
Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP (By similarity).
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Uniprot ID
Q6R6I6
Ensembl ID
ENSG00000171509
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0911989
 Compound Info 
Relaxin
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C253H407N73O72S8
  1
1
EC50 = 0.5 nM
 Bioactivity Info 
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CP0911718
 Compound Info 
(3S,6S,9S,49S,52S,55S,59S,62S,65S,68S,71S,77S,80S,84S,88S,91S,94S,97S,100S,103S,106S,109S,112S,118S)-62-((1H-indol-3-yl)methyl)-118-((S)-2-acetamido-4-methylpentanamido)-3-((S)-1-amino-1,5-dioxohenicosan-4-ylcarbamoyl)-91-(3-amino-3-oxopropyl)-9,49,103-tris(4-aminobutyl)-88-sec-butyl-6,77,106,112-tetrakis(2-carboxyethyl)-52,97,109-tris(3-guanidinopropyl)-65-((R)-1-hydroxyethyl)-59,68-bis(hydroxymethyl)-100-isopropyl-55,80,84,94-tetramethyl-71-(2-(methylthio)ethyl)-5,8,11,48,51,54,58,61,64,67,70,73,76,79,83,87,90,93,96,99,102,105,108,111,114,117-hexacosaoxo-14,17,20,23,26,29,32,35,38,41,44-undecaoxa-4,7,10,47,50,53,57,60,63,66,69,72,75,78,82,86,89,92,95,98,101,104,107,110,113,116-hexacosaazaicosahectane-1,120-dicarboxylic acid
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C181H314N44O58S
  1
1
EC50 = 0.9 nM
 Bioactivity Info 
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CP0962477
 Compound Info 
(3S,6S,10S,14S,17S,20S,23S,26S,29S,32S,35S,41S)-3-((4S,7S,10S,13S,16S,20S,23S,26S,29S)-13-((1H-indol-3-yl)methyl)-33-amino-26-(4-aminobutyl)-4-butyl-29-carbamoyl-23-(3-guanidinopropyl)-10-((R)-1-hydroxyethyl)-7,16-bis(hydroxymethyl)-20-methyl-2,5,8,11,14,17,21,24,27-nonaoxo-3,6,9,12,15,18,22,25,28-nonaazatritriacontylcarbamoyl)-41-((S)-2-acetamido-4-methylpentanamido)-17-(3-amino-3-oxopropyl)-29-(4-aminobutyl)-14-sec-butyl-32-(2-carboxyethyl)-23,35-bis(3-guanidinopropyl)-26-isopropyl-6,10,20-trimethyl-5,9,13,16,19,22,25,28,31,34,37,40-dodecaoxo-4,8,12,15,18,21,24,27,30,33,36,39-dodecaazatritetracontane-1,43-dicarboxylic acid
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C121H207N39O35
  1
1
EC50 = 5.3 nM
 Bioactivity Info 
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Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT05999 Relaxin receptor 1 Homo sapiens, Human
 Protein Info