General Information of the Protein
Protein ID
PT07467
Protein Name
Potassium channel subfamily T member 1
Gene Name
KCNT1
Secondarily
Gene Name
Kiaa1422
Sequence
MARAKLPRSPSEGKAGPGDTPAGAAAPEEPHGLSPLLPARGGGSVGSDVGQRVQVEFYVNENTFKERLKLFFIKNQRSSLRIRLFNFSLKLLTCLLYIVRVLLDNPDQGIGCWGCTKYNYTFNGSSSEFHWAPILWVERKMALWVIQVIVATISFLETMLIIYLSYKGNIWEQIFHVSFVLEMINTLPFIITVFWPPLRNLFIPVFLNCWLAKHALENMINDFHRAILRTQSAMFNQVLILFCTLLCLVFTGTCGIQHLERAGGNLNLLTSFYFCIVTFSTVGFGDVTPKIWPSQLLVVILICVTLVVLPLQFEELVYLWMERQKSGGNYSRHRARTEKHVVLCVSSLKIDLLMDFLNEFYAHPRLQDYYVVILCPSEMDVQVRRVLQIPLWSQRVIYLQGSALKDQDLMRAKMDNGEACFILSSRNEVDRTAADHQTILRAWAVKDFAPNCPLYVQILKPENKFHVKFADHVVCEEECKYAMLALNCICPATSTLITLLVHTSRGQEGQESPEQWQRTYGRCSGNEVYHIRMGDSKFFREYEGKSFTYAAFHAHKKYGVCLIGLKREENKSILLNPGPRHILAASDTCFYINITKEENSAFIFKQEEKQKRRGLAGQALYEGPSRLPVHSIIASMGTVAMDLQNTDCRPSQGGSGGDGTKLTLPTENGSGSRRPSIAPVLELADSSALLPCDLLSDQSEDEVTPSDDEGLSVVEYVKGYPPNSPYIGSSPTLCHLLPVKAPFCCLRLDKGCKHNSYEDAKAYGFKNKLIIVSAETAGNGLYNFIVPLRAYYRSRRELNPIVLLLDNKPDHHFLEAICCFPMVYYMEGSVDNLDSLLQCGIIYADNLVVVDKESTMSAEEDYMADAKTIVNVQTMFRLFPSLSITTELTHPSNMRFMQFRAKDSYSLALSKLEKQERENGSNLAFMFRLPFAAGRVFSISMLDTLLYQSFVKDYMITITRLLLGLDTTPGSGYLCAMKVTEDDLWIRTYGRLFQKLCSSSAEIPIGIYRTECHVFSEPHDVRAQSQISVNMEDCEDTREAKGPWGTRAASGSGSTHGRHGGSADPVEHPLLRRKSLQWARKLSRKSTKQAGKAPVATDWITQQRLSLYRRSERQELSELVKNRMKHLGLPTTGYEDVANLTASDVMNRVNLGYLQDEMNDHHQNTLSYVLINPPPDTRLEPNDIVYLIRSDPLAHVASSSQSRKSSCSNKLSSCNPETRDETQL
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Organism
Mus musculus, Mouse
Protein Classification
Unclassified protein
Function
Outwardly rectifying potassium channel subunit that may coassemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro) (By similarity).
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Uniprot ID
Primary ID:
Q6ZPR4

Secondarily ID:
B2RUK3
Q8C3E7
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Ensembl ID
ENSG00000107147
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000058 , T-REx-293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0537139
 Compound Info 
2-methyl-5-(trifluoromethyl)-N-[(1S)-1-[3-[2-(trifluoromethyl)pyridin-4-yl]-1,2,4-oxadiazol-5-yl]ethyl]pyrazole-3-carboxamide
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C16H12F6N6O2
  1
1
IC50 = 622 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0556950
 Compound Info 
N-[(1S)-1-[3-(2-cyclopropylpyridin-4-yl)-1,2,4-oxadiazol-5-yl]ethyl]-2-methyl-5-(trifluoromethyl)pyrazole-3-carboxamide
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C18H17F3N6O2
  1
1
IC50 = 1143 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0565077
 Compound Info 
N-[(1S)-1-[3-[2-(difluoromethyl)pyridin-4-yl]-1,2,4-oxadiazol-5-yl]ethyl]-2-methyl-5-(trifluoromethyl)pyrazole-3-carboxamide
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C16H13F5N6O2
  1
1
IC50 = 1251 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0444680
 Compound Info 
N-[(1S)-1-[3-(2-methoxypyridin-4-yl)-1,2,4-oxadiazol-5-yl]ethyl]-2-methyl-5-(trifluoromethyl)pyrazole-3-carboxamide
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C16H15F3N6O3
  1
1
IC50 = 3001 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0563812
 Compound Info 
2-methyl-N-[(1S)-1-[3-(2-methylpyridin-4-yl)-1,2,4-oxadiazol-5-yl]ethyl]-5-(trifluoromethyl)pyrazole-3-carboxamide
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C16H15F3N6O2
  1
1
IC50 = 14500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0551767
 Compound Info 
N-[(1S)-1-[3-[2-(methoxymethyl)pyridin-4-yl]-1,2,4-oxadiazol-5-yl]ethyl]-2-methyl-5-(trifluoromethyl)pyrazole-3-carboxamide
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C17H17F3N6O3
  1
1
IC50 = 17140 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0451217
 Compound Info 
2-methyl-N-[(1S)-1-[3-[2-(methylamino)pyridin-4-yl]-1,2,4-oxadiazol-5-yl]ethyl]-5-(trifluoromethyl)pyrazole-3-carboxamide
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C16H16F3N7O2
  1
1
IC50 > 30000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT07735 Potassium channel subfamily T member 1 Rattus norvegicus, Rat
 Protein Info