General Information of the Protein
Protein ID
PT07343
Protein Name
Methionine--tRNA ligase, mitochondrial
Secondarily
Protein Name
Methionyl-tRNA synthetase 2
Mitochondrial methionyl-tRNA synthetase
Gene Name
MARS2
Sequence
MLRTSVLRLLGRTGASRLSLLEDFGPRYYSSGSLSAGDDACDVRAYFTTPIFYVNAAPHIGHLYSALLADALCRHRRLRGPSTAATRFSTGTDEHGLKIQQAAATAGLAPTELCDRVSEQFQQLFQEAGISCTDFIRTTEARHRVAVQHFWGVLKSRGLLYKGVYEGWYCASDECFLPEAKVTQQPGPSGDSFPVSLESGHPVSWTKEENYIFRLSQFRKPLQRWLRGNPQAITPEPFHHVVLQWLDEELPDLSVSRRSSHLHWGIPVPGDDSQTIYVWLDALVNYLTVIGYPNAEFKSWWPATSHIIGKDILKFHAIYWPAFLLGAGMSPPQRICVHSHWTVCGQKMSKSLGNVVDPRTCLNRYTVDGFRYFLLRQGVPNWDCDYYDEKVVKLLNSELADALGGLLNRCTAKRINPSETYPAFCTTCFPSEPGLVGPSVRAQAEDYALVSAVATLPKQVADHYDNFRIYKALEAVSSCVRQTNGFVQRHAPWKLNWESPVDAPWLGTVLHVALECLRVFGTLLQPVTPSLADKLLSRLGVSASERSLGELYFLPRFYGHPCPFEGRRLGPETGLLFPRLDQSRTWLVKAHRT
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Ligase
Uniprot ID
Primary ID:
Q96GW9

Secondarily ID:
A0AVC3
Q76E79
Q8IW62
Q8N7N4
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Ensembl ID
ENSG00000247626
HGNC ID
HGNC:25133
Subcellular Location
Mitochondrion matrix
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000063 , Hep-G2
Compound ID Compound Name Compound Formula
CP0562193
1-[(5-chloro-1H-imidazo[4,5-b]pyridin-2-yl)methyl]-4-[(2-chloro-4-methoxyphenyl)methyl]-3-ethylimidazol-2-one
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C20H19Cl2N5O2
 1
1
EC50 = 39 nM
   TI
   LI
   LO
   TS
CP0556802
1-[(5-chloro-1H-imidazo[4,5-b]pyridin-2-yl)methyl]-4-[(2,4-dichlorophenyl)methyl]-3-ethylimidazol-2-one
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C19H16Cl3N5O
 1
1
EC50 = 42 nM
   TI
   LI
   LO
   TS
CP0579090
4-[(2-chloro-4-methoxyphenyl)methyl]-3-ethyl-1-[(5-fluoro-1H-imidazo[4,5-b]pyridin-2-yl)methyl]imidazol-2-one
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C20H19ClFN5O2
 1
1
EC50 = 75 nM
   TI
   LI
   LO
   TS
CP0571963
4-[(2,4-dichlorophenyl)methyl]-3-(2,2-difluoroethyl)-1-[(5-fluoro-1H-imidazo[4,5-b]pyridin-2-yl)methyl]imidazol-2-one
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C19H14Cl2F3N5O
 1
1
EC50 = 175 nM
   TI
   LI
   LO
   TS
CP0560240
4-[(2,4-dichlorophenyl)methyl]-1-[(5-fluoro-1H-imidazo[4,5-b]pyridin-2-yl)methyl]-3-propylimidazol-2-one
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C20H18Cl2FN5O
 1
1
EC50 = 195 nM
   TI
   LI
   LO
   TS
CP0560239
4-[(2,4-dichlorophenyl)methyl]-3-ethyl-1-[(5-fluoro-1H-imidazo[4,5-b]pyridin-2-yl)methyl]imidazol-2-one
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C19H16Cl2FN5O
 1
1
EC50 = 290 nM
   TI
   LI
   LO
   TS
CP0562194
2-[[5-(2-chloro-4,5-dimethoxyphenyl)imidazo[1,2-a]pyridin-2-yl]methyl]-5-fluoro-1H-imidazo[4,5-b]pyridine
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C22H17ClFN5O2
 1
1
EC50 = 316 nM
   TI
   LI
   LO
   TS
CP0571962
1-[(5-chloro-1H-imidazo[4,5-b]pyridin-2-yl)methyl]-4-[(2,4-dichlorophenyl)methyl]-3-(2,2-difluoroethyl)imidazol-2-one
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C19H14Cl3F2N5O
 1
1
EC50 = 430 nM
   TI
   LI
   LO
   TS
CP0511957
5-chloro-2-[[5-(2-chloro-4,5-dimethoxyphenyl)imidazo[1,2-a]pyridin-2-yl]methyl]-1H-imidazo[4,5-b]pyridine
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C22H17Cl2N5O2
 1
1
EC50 = 478 nM
   TI
   LI
   LO
   TS
CP0574459
5-chloro-2-[[5-(2,4-dichloro-5-methoxyphenyl)imidazo[1,2-a]pyridin-2-yl]methyl]-1H-imidazo[4,5-b]pyridine
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C21H14Cl3N5O
 1
1
EC50 = 507 nM
   TI
   LI
   LO
   TS
CP0537129
2-[[5-(2,4-dichloro-5-methoxyphenyl)imidazo[1,2-a]pyridin-2-yl]methyl]-5-fluoro-1H-imidazo[4,5-b]pyridine
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C21H14Cl2FN5O
 1
1
EC50 = 1750 nM
   TI
   LI
   LO
   TS
CP0069840
2,2-dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide
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C11H12Cl2N2O5
 1
1
EC50 = 7900 nM
   TI
   LI
   LO
   TS