General Information of the Protein
Protein ID
PT07180
Protein Name
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
Secondarily
Protein Name
G1 to S phase transition protein 1 homolog
Gene Name
GSPT1
Secondarily
Gene Name
ERF3A
Sequence
MELSEPIVENGETEMSPEESWEHKEEISEAEPGGGSLGDGRPPEESAHEMMEEEEEIPKPKSVVAPPGAPKKEHVNVVFIGHVDAGKSTIGGQIMYLTGMVDKRTLEKYEREAKEKNRETWYLSWALDTNQEERDKGKTVEVGRAYFETEKKHFTILDAPGHKSFVPNMIGGASQADLAVLVISARKGEFETGFEKGGQTREHAMLAKTAGVKHLIVLINKMDDPTVNWSNERYEECKEKLVPFLKKVGFNPKKDIHFMPCSGLTGANLKEQSDFCPWYIGLPFIPYLDNLPNFNRSVDGPIRLPIVDKYKDMGTVVLGKLESGSICKGQQLVMMPNKHNVEVLGILSDDVETDTVAPGENLKIRLKGIEEEEILPGFILCDPNNLCHSGRTFDAQIVIIEHKSIICPGYNAVLHIHTCIEEVEITALICLVDKKSGEKSKTRPRFVKQDQVCIARLRTAGTICLETFKDFPQMGRFTLRDEGKTIAIGKVLKLVPEKD
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Organism
Homo sapiens, Human
Protein Classification
Unclassified protein
Function
GTPase component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons UAA, UAG and UGA (PubMed:2511002, PubMed:15987998, PubMed:19417105, PubMed:27863242). GSPT1/ERF3A mediates ETF1/ERF1 delivery to stop codons: The eRF1-eRF3-GTP complex binds to a stop codon in the ribosomal A-site (PubMed:27863242). GTP hydrolysis by GSPT1/ERF3A induces a conformational change that leads to its dissociation, permitting ETF1/ERF1 to accommodate fully in the A-site (PubMed:16777602, PubMed:27863242). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:24486019). Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes (PubMed:30682371).
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Uniprot ID
Primary ID:
P15170

Secondarily ID:
J3KQG6
Q96GF2
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Ensembl ID
ENSG00000103342
HGNC ID
HGNC:4621
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000362 , GripTite 293 MSR
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0950511
 Compound Info 
3-((4-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)piperidin-1-yl)methyl)benzamide
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C26H28N4O4
  1
1
EC50 > 30000 nM
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CP0950513
 Compound Info 
3-(5-(1-((1-cyclobutyl-1H-1,2,3-triazol-4-yl)methyl)piperidin-4-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
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C25H30N6O3
  1
1
EC50 > 30000 nM
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CP0950514
 Compound Info 
3-(1-oxo-5-(1-(pyrazolo[1,5-a]pyridin-4-ylmethyl)piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione
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C26H27N5O3
  1
1
EC50 > 30000 nM
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CP0950520
 Compound Info 
3-(1-oxo-5-(1-(quinoxalin-6-ylmethyl)piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione
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C27H27N5O3
  1
1
EC50 > 30000 nM
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CP0951096
 Compound Info 
3-(5-(1-(4-(5-methylbenzo[d]thiazol-2-yl)benzyl)piperidin-4-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
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C33H32N4O3S
  1
1
EC50 > 30000 nM
 Bioactivity Info 
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CP0951104
 Compound Info 
3-(1-oxo-5-(1-((4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)methyl)piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione
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C25H25N5O4S
  1
1
EC50 > 30000 nM
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CP0951107
 Compound Info 
3-(5-(1-((1H-indol-2-yl)methyl)piperidin-4-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
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C27H28N4O3
  1
1
EC50 > 30000 nM
 Bioactivity Info 
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CP0951113
 Compound Info 
3-(1-oxo-5-(1-((4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-2-yl)methyl)piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione
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C26H31N5O3
  1
1
EC50 > 30000 nM
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CP0951120
 Compound Info 
4-((4-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)piperidin-1-yl)methyl)benzamide
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C26H28N4O4
  1
1
EC50 > 30000 nM
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CP0951128
 Compound Info 
3-(5-(1-(4-(1H-pyrazol-1-yl)benzyl)piperidin-4-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
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C28H29N5O3
  1
1
EC50 > 30000 nM
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CP0951129
 Compound Info 
3-(5-(1-((1-methyl-1H-indazol-3-yl)methyl)piperidin-4-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
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C27H29N5O3
  1
1
EC50 > 30000 nM
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CP0951130
 Compound Info 
3-(5-(1-((7-fluoroquinolin-2-yl)methyl)piperidin-4-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
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C28H27FN4O3
  1
1
EC50 > 30000 nM
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CP0951131
 Compound Info 
3-(5-(1-((6-methyl-1H-indol-3-yl)methyl)piperidin-4-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
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C28H30N4O3
  1
1
EC50 > 30000 nM
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CP0951132
 Compound Info 
3-(5-(1-(benzo[d]thiazol-5-ylmethyl)piperidin-4-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
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C26H26N4O3S
  1
1
EC50 > 30000 nM
 Bioactivity Info 
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CP0951267
 Compound Info 
3-(5-(1-(3-isopropoxybenzyl)piperidin-4-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
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C28H33N3O4
  1
1
EC50 > 30000 nM
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CP0951270
 Compound Info 
3-(5-(1-(4-cyclopentylbenzyl)piperidin-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
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C30H35N3O3
  1
1
EC50 > 30000 nM
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CP0951272
 Compound Info 
3-(1-oxo-5-(1-(4-(tert-pentyl)benzyl)piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione
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C30H37N3O3
  1
1
EC50 > 30000 nM
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CP0954468
 Compound Info 
rac 3-(1-oxo-5-(1-(1-phenylethyl)piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione
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C26H29N3O3
  1
1
EC50 > 30000 nM
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CP0955081
 Compound Info 
3-(5-(1-(3-(tert-butyl)benzyl)piperidin-4-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
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C29H35N3O3
  1
1
EC50 > 30000 nM
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CP0959276
 Compound Info 
4-((4-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)piperidin-1-yl)methyl)-N,N-dimethylbenzenesulfonamide
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C27H32N4O5S
  1
1
EC50 > 30000 nM
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CP0959277
 Compound Info 
3-(5-(1-((5-methyl-3-phenylisoxazol-4-yl)methyl)piperidin-4-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
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C29H30N4O4
  1
1
EC50 > 30000 nM
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CP0960547
 Compound Info 
N-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)piperidin-1-yl)methyl)phenyl)acetamide
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C27H30N4O4
  1
1
EC50 > 30000 nM
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CP0960548
 Compound Info 
3-(5-(1-((6-methylimidazo[2,1-b]thiazol-5-yl)methyl)piperidin-4-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
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C25H27N5O3S
  1
1
EC50 > 30000 nM
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CP0960551
 Compound Info 
2-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)piperidin-l-yl)methyl)phenyl)acetonitrile
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C27H28N4O3
  1
1
EC50 > 30000 nM
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CP0960552
 Compound Info 
3-(1-oxo-5-(1-((2-(pyrrolidin-1-yl)pyrimidin-5-yl)methyl)piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione
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C27H32N6O3
  1
1
EC50 > 30000 nM
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CP0960757
 Compound Info 
3-(5-(1-(2,4-dichlorobenzyl)piperidin-4-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
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C25H25Cl2N3O3
  1
1
EC50 > 30000 nM
 Bioactivity Info 
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CP0964072
 Compound Info 
3-(5-(1-(4-(difluoromethyl)benzyl)piperidin-4-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
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C26H27F2N3O3
  1
1
EC50 > 30000 nM
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CP0964074
 Compound Info 
3-(5-(1-((2-morpholinopyrimidin-5-yl)methyl)piperidin-4-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
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C27H32N6O4
  1
1
EC50 > 30000 nM
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CP0965583
 Compound Info 
3-(5-(1-(3,4-difluorobenzyl)piperidin-4-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
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C25H25F2N3O3
  1
1
EC50 > 30000 nM
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CP0965584
 Compound Info 
3-((4-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)piperidin-1-yl)methyl)benzonitrile
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C26H26N4O3
  1
1
EC50 > 30000 nM
 Bioactivity Info 
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CP0965598
 Compound Info 
3-(5-(1-((2-(tert-butyl)thiazol-4-yl)methyl)piperidin-4-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
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C26H32N4O3S
  1
1
EC50 > 30000 nM
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CP0965605
 Compound Info 
3-(1-oxo-5-(1-((4-phenyl-1H-imidazol-2-yl)methyl)piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione
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C28H29N5O3
  1
1
EC50 > 30000 nM
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CP0966496
 Compound Info 
3-(1-oxo-5-(1-(pyridin-3-ylmethyl)piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione
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C24H26N4O3
  1
1
EC50 > 30000 nM
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CP0966504
 Compound Info 
3-(5-(1-((1H-indazol-6-yl)methyl)piperidin-4-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
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C26H27N5O3
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1
EC50 > 30000 nM
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CP0967208
 Compound Info 
3-(5-(1-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)methyl)piperidin-4-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
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C28H31N3O5
  1
1
EC50 > 30000 nM
 Bioactivity Info 
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CP0967209
 Compound Info 
3-(5-(1-(4-(difluoromethoxy)benzyl)piperidin-4-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
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C26H27F2N3O4
  1
1
EC50 > 30000 nM
 Bioactivity Info 
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CP0968022
 Compound Info 
3-(1-oxo-5-(1-(quinolin-4-ylmethyl)piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione
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C28H28N4O3
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1
EC50 > 30000 nM
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CP0968030
 Compound Info 
3-(5-(1((1H-indazol-4-yl)methyl)piperidin-4-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
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C26H27N5O3
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1
EC50 > 30000 nM
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CP0968031
 Compound Info 
3-((4-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)piperidin-1-yl)methyl)-N,N-dimethylbenzenesulfonamide
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C27H32N4O5S
  1
1
EC50 > 30000 nM
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CP0968111
 Compound Info 
3-(5-(1-((2-methoxypyrimidin-5-yl)methyl)piperidin-4-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
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C24H27N5O4
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1
EC50 > 30000 nM
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CP0968112
 Compound Info 
3-(1-oxo-5-(1-((2-phenylthiazol-4-yl)methyl)piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione
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C28H28N4O3S
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1
EC50 > 30000 nM
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CP0968766
 Compound Info 
3-(5-(1-(4-hydroxy-3-((4-methylpiperazin-1-yl)methyl)benzyl)piperidin-4-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
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C31H39N5O4
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1
EC50 > 30000 nM
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CP0950502
 Compound Info 
3-(5-((R)-azepan-4-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
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C19H23N3O3
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1
EC50 > 50000 nM
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CP0950503
 Compound Info 
3-(1-oxo-5-(1-phenylpiperidin-4-yl)isoindolin-2-yl)piperidine-26-dione
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C24H25N3O3
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1
EC50 > 50000 nM
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CP0950504
 Compound Info 
3-(5-(1-(cyclohexylmethyl)piperidin-4-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
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C25H33N3O3
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1
EC50 > 50000 nM
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CP0950505
 Compound Info 
3-(5-(1-(2-methylbenzyl)piperidin-4-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
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C26H29N3O3
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1
EC50 > 50000 nM
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CP0950506
 Compound Info 
3-(5-(1-(4-cyanobenzyl)piperidin-4-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
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C26H26N4O3
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1
EC50 > 50000 nM
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CP0950519
 Compound Info 
3-(5-(1-(4-methoxybenzyl)piperidin-4-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione formate
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C27H31N3O6
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1
EC50 > 50000 nM
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CP0951124
 Compound Info 
methyl 2-(4-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)piperidin-1-yl)acetate
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C21H25N3O5
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1
EC50 > 50000 nM
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CP0951125
 Compound Info 
3-(5-(1-benzylpiperidin-4-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
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C25H27N3O3
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1
EC50 > 50000 nM
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CP0951126
 Compound Info 
3-(5-(1-(4-methylbenzyl)piperidin-4-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
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C26H29N3O3
  1
1
EC50 > 50000 nM
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CP0951127
 Compound Info 
3-(5-(1-(3,5-difluoro-4-hydroxybenzyl)piperidin-4-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
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C25H25F2N3O4
  1
1
EC50 > 50000 nM
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CP0951268
 Compound Info 
3-(1-oxo-5-(piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione Hydrochloride
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C18H22ClN3O3
  1
1
EC50 > 50000 nM
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CP0951269
 Compound Info 
3-(1-oxo-5-(1-((5,6,7,8-tetrahydronaphthalen-1-yl)methyl)piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione
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C29H33N3O3
  1
1
EC50 > 50000 nM
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CP0954469
 Compound Info 
3-(5-(1-(4-fluorobenzyl)piperidin-4-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione formate
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C26H28FN3O5
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1
EC50 > 50000 nM
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CP0960550
 Compound Info 
3-(5-((2S)-1-benzyl-2-methylpiperidin-4-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione formate
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C27H31N3O5
  1
1
EC50 > 50000 nM
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CP0964110
 Compound Info 
3-(5-((S)-azepan-4-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
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C19H23N3O3
  1
1
EC50 > 50000 nM
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CP0965602
 Compound Info 
3-(1-oxo-5-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione
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C20H22F3N3O3
  1
1
EC50 > 50000 nM
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CP0965980
 Compound Info 
3-(5-(1-([1,1'-biphenyl]-4-ylmethyl)piperidin-4-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
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C31H31N3O3
  1
1
EC50 > 50000 nM
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CP0966466
 Compound Info 
3-(5-(1-(3,5-dimethylbenzyl)piperidin-4-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
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C27H31N3O3
  1
1
EC50 > 50000 nM
 Bioactivity Info 
   TI
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   LO
   TS
CP0966503
 Compound Info 
tert-butyl 2-(4-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)piperidin-1-yl)acetate
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C24H31N3O5
  1
1
EC50 > 50000 nM
 Bioactivity Info 
   TI
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   LO
   TS
CP0968222
 Compound Info 
3-(5-(1-(4-chlorobenzyl)piperidin-4-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
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C25H26ClN3O3
  1
1
EC50 > 50000 nM
 Bioactivity Info 
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CP0968474
 Compound Info 
3-(5-(1-((1H-pyrazol-3-yl)methyl)piperidin-4-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
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C22H25N5O3
  1
1
EC50 > 50000 nM
 Bioactivity Info 
   TI
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   TS
CP0969278
 Compound Info 
3-(5-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
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C19H21N3O3
  1
1
EC50 > 50000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0969279
 Compound Info 
3-(1-oxo-5-(1-((1,2,3,4-tetrahydronaphthalen-1-yl)methyl)piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione
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C29H33N3O3
  1
1
EC50 > 50000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS