General Information of the Protein
Protein ID
PT07116
Protein Name
Fibroblast growth factor 23
Secondarily
Protein Name
Phosphatonin
Tumor-derived hypophosphatemia-inducing factor
Gene Name
FGF23
Secondarily
Gene Name
HYPF
UNQ3027/PRO9828
Sequence
MLGARLRLWVCALCSVCSMSVLRAYPNASPLLGSSWGGLIHLYTATARNSYHLQIHKNGHVDGAPHQTIYSALMIRSEDAGFVVITGVMSRRYLCMDFRGNIFGSHYFDPENCRFQHQTLENGYDVYHSPQYHFLVSLGRAKRAFLPGMNPPPYSQFLSRRNEIPLIHFNTPIPRRHTRSAEDDSERDPLNVLKPRARMTPAPASCSQELPSAEDNSPMASDPLGVVRGGRVNTHAGGTGPEGCRPFAKFI
    Show/Hide
Organism
Homo sapiens, Human
Protein Classification
Secreted protein
Function
Regulator of phosphate homeostasis (PubMed:11062477). Inhibits renal tubular phosphate transport by reducing SLC34A1 levels (PubMed:11409890). Up-regulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism (PubMed:15040831). Negatively regulates osteoblast differentiation and matrix mineralization (PubMed:18282132).
    Show/Hide
Uniprot ID
Primary ID:
Q9GZV9

Secondarily ID:
Q4V758
    Show/Hide
HGNC ID
HGNC:3680
Subcellular Location
Secreted
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000025 , HEK-293T
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0470054
 Compound Info 
(NE)-N-[[2-[(E)-2-(4-methylphenyl)ethenyl]phenyl]methylidene]hydroxylamine
   Show/Hide
C16H15NO
  1
1
IC50 = 140 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0562010
 Compound Info 
(NE)-N-[[2-[(E)-2-(4-methylphenyl)ethenyl]cyclopenten-1-yl]methylidene]hydroxylamine
   Show/Hide
C15H17NO
  1
1
IC50 = 200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0552105
 Compound Info 
(NE)-N-[[2-[(E)-2-(4-fluorophenyl)ethenyl]cyclopenten-1-yl]methylidene]hydroxylamine
   Show/Hide
C14H14FNO
  1
1
IC50 = 370 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0470052
 Compound Info 
(NE)-N-[[2-[(E)-2-(4-methylphenyl)ethenyl]pyridin-3-yl]methylidene]hydroxylamine
   Show/Hide
C15H14N2O
  1
1
IC50 = 390 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0552104
 Compound Info 
(NE)-N-[[2-[(E)-2-(4-methylphenyl)ethenyl]cyclohexen-1-yl]methylidene]hydroxylamine
   Show/Hide
C16H19NO
  1
1
IC50 = 520 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0552106
 Compound Info 
(NE)-N-[[2-(4-tert-butylphenyl)cyclopenten-1-yl]methylidene]hydroxylamine
   Show/Hide
C16H21NO
  1
1
IC50 = 2790 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0565131
 Compound Info 
(NE)-N-[[2-[(E)-2-phenylethenyl]cyclopenten-1-yl]methylidene]hydroxylamine
   Show/Hide
C14H15NO
  1
1
IC50 = 5000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0552985
 Compound Info 
(NE)-N-[(2-phenylcyclopenten-1-yl)methylidene]hydroxylamine
   Show/Hide
C12H13NO
  1
1
IC50 = 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0470053
 Compound Info 
(NE)-N-[[2-(4-methoxyphenyl)cyclopenten-1-yl]methylidene]hydroxylamine
   Show/Hide
C13H15NO2
  1
1
IC50 = 12300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Clinical Information about the Protein
Target 1 ( Fibroblast growth factor-23 (FGF23) )
Target Type Successful Target