General Information of the Protein
Protein ID
PT07038
Protein Name
Growth hormone-releasing hormone receptor
Secondarily
Protein Name
Growth hormone-releasing factor receptor
Gene Name
GHRHR
Sequence
MDRRMWGAHVFCVLSPLPTVLGHMHPECDFITQLREDESACLQAAEEMPNTTLGCPATWDGLLCWPTAGSGEWVTLPCPDFFSHFSSESGAVKRDCTITGWSEPFPPYPVACPVPLELLAEEESYFSTVKIIYTVGHSISIVALFVAITILVALRRLHCPRNYVHTQLFTTFILKAGAVFLKDAALFHSDDTDHCSFSTVLCKVSVAASHFATMTNFSWLLAEAVYLNCLLASTSPSSRRAFWWLVLAGWGLPVLFTGTWVSCKLAFEDIACWDLDDTSPYWWIIKGPIVLSVGVNFGLFLNIIRILVRKLEPAQGSLHTQSQYWRLSKSTLFLIPLFGIHYIIFNFLPDNAGLGIRLPLELGLGSFQGFIVAILYCFLNQEVRTEISRKWHGHDPELLPAWRTRAKWTTPSRSAAKVLTSMC
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Organism
Homo sapiens, Human
Protein Classification
Membrane receptor
>
Family B G protein-coupled receptor
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Peptide receptor (family B GPCR)
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Glucagon-like receptor
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Growth hormone-releasing hormone receptor
Function
Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion.
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Uniprot ID
Primary ID:
Q02643

Secondarily ID:
Q99863
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HGNC ID
HGNC:4266
Subcellular Location
Cell membrane
Clinical Information about the Protein
Target 1 ( Growth hormone-releasing hormone receptor (GHRHR) )
Target Type Successful Target
Disease 2 Target-related Diseases  2
1 Pediatric growth disorder [ICD-11: FB86]
2 Growth hormone deficiency [ICD-11: 5A61.3]
Approved Drug(s) 1 Approved Drug  1
1 Sermorelin
 Drug Info 
Approved
Pediatric growth disorder
Discontinued Drug(s) 2 Discontinued Drugs  2
1 Examorelin
 Drug Info 
Discontinued in Phase 2
Growth hormone deficiency
2 L-692429
 Drug Info 
Discontinued in Phase 1
Growth hormone deficiency