General Information of the Protein
Protein ID
PT06961
Protein Name
Matrix metalloproteinase-9
Secondarily
Protein Name
92 kDa gelatinase
92 kDa type IV collagenase
Gelatinase B
Gene Name
MMP9
Sequence
MSPLQPLVLALLVLACCSAVPRRRQPTVVVFPGEPRTNLTNRQLAEEYLYRYGYTPGAELSEDGQSLQRALLRFQRRLSLPETGELDSTTLNAMRAPRCGVPDVGRFQTFEGELKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYGPEADIVIQFGVREHGDGYPFDGKNGLLAHAFPPGKGIQGDAHFDDEELWSLGKGVVIPTYFGNAKGAACHFPFTFEGRSYSACTTDGRSDDMLWCSTTADYDADRQFGFCPSERLYTQDGNADGKPCVFPFTFQGRTYSACTSDGRSDGYRWCATTANYDQDKLYGFCPTRVDATVTGGNAAGELCVFPFTFLGKEYSACTREGRNDGHLWCATTSNFDKDKKWGFCPDQGYSLFLVAAHEFGHALGLDHTSVPEALMYPMYRFTEEHPLHRDDVQGIQHLYGPRPEPEPRPPTTTTTTTTEPQPTAPPTVCVTGPPTARPSEGPTTGPTGPPAAGPTGPPTAGPSAAPTESPDPAEDVCNVDIFDAIAEIRNRLHFFKAGKYWRLSEGGGRRVQGPFLVKSKWPALPRKLDSAFEDPLTKKIFFFSGRQVWVYTGASLLGPRRLDKLGLGPEVAQVTGALPRPEGKVLLFSGQSFWRFDVKTQKVDPQSVTPVDQMFPGVPISTHDIFQYQEKAYFCQDHFYWRVSSQNEVNQVDYVGYVTFDLLKCPED
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Organism
Bos taurus, Bovine
Protein Classification
Enzyme
>
Protease
>
Metallo protease
>
Metallo protease MAM clan
>
Metallo protease M10A subfamily
Function
Matrix metalloproteinase that plays an essential role in local proteolysis of the extracellular matrix and in leukocyte migration (By similarity). Could play a role in bone osteoclastic resorption (By similarity). Cleaves KiSS1 at a Gly-|-Leu bond (By similarity). Cleaves NINJ1 to generate the Secreted ninjurin-1 form (By similarity). Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide (By similarity).
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Uniprot ID
Primary ID:
P52176

Secondarily ID:
A5PKB8
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Ensembl ID
ENSG00000100985
Subcellular Location
Secreted
Extracellular space
Extracellular matrix
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000879 , BAE1
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0318932
 Compound Info 
[(2S)-1-[(2-methylpropan-2-yl)oxy]-3-(2-nitroimidazol-1-yl)propan-2-yl] 4-[(2-hydroxy-5-oxocyclopenta-1,3-dien-1-yl)methylideneamino]benzoate
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C23H24N4O7
  1
1
IC50 = 7.8125 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0173070
 Compound Info 
[(2S)-1-(4-tert-butylphenoxy)-3-(2-nitroimidazol-1-yl)propan-2-yl] 4-[(2-hydroxy-5-oxocyclopenta-1,3-dien-1-yl)methylideneamino]benzoate
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C29H28N4O7
  1
1
IC50 = 9.708738 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0247154
 Compound Info 
[(2R)-1-[(2-methylpropan-2-yl)oxy]-3-(2-nitroimidazol-1-yl)propan-2-yl] 4-[(2-hydroxy-5-oxocyclopenta-1,3-dien-1-yl)methylideneamino]benzoate
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C23H24N4O7
  1
1
IC50 = 9.803922 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0345034
 Compound Info 
[(2R)-1-(4-tert-butylphenoxy)-3-(2-nitroimidazol-1-yl)propan-2-yl] 4-[(2-hydroxy-5-oxocyclopenta-1,3-dien-1-yl)methylideneamino]benzoate
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C29H28N4O7
  1
1
IC50 = 14.925373 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0319919
 Compound Info 
[(2R)-1-methoxy-3-(2-nitroimidazol-1-yl)propan-2-yl] 4-[(2-hydroxy-5-oxocyclopenta-1,3-dien-1-yl)methylideneamino]benzoate
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C20H18N4O7
  1
1
IC50 = 18.867925 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0222498
 Compound Info 
[(2R)-1-methoxy-3-(2-nitroimidazol-1-yl)propan-2-yl] 4-[(2,2,2-trifluoroacetyl)amino]benzoate
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C16H15F3N4O6
  1
1
IC50 > 4.166667 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0318931
 Compound Info 
[(2S)-1-methoxy-3-(2-nitroimidazol-1-yl)propan-2-yl] 4-[(2,2,2-trifluoroacetyl)amino]benzoate
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C16H15F3N4O6
  1
1
IC50 > 4.166667 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT00849 Matrix metalloproteinase-9 Homo sapiens, Human
 Protein Info