General Information of the Protein
Protein ID
PT06939
Protein Name
Presenilin-2
Secondarily
Protein Name
AD3LP
AD5
E5-1
STM-2
Gene Name
PSEN2
Secondarily
Gene Name
AD4
PS2
PSNL2
STM2
Sequence
MLTFMASDSEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDPDRYVCSGVPGRPPGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMALVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQLPYDPEMEEDSYDSFGEPSYPEVFEPPLTGYPGEELEEEEERGVKLGLGDFIFYSVLVGKAAATGSGDWNTTLACFVAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNLVRPFMDTLASHQLYI
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Organism
Homo sapiens, Human
Protein Classification
Ion channel
>
Other ion channel
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Miscellaneous ion channel
>
Presenilin ER Ca2+ leak channel family
Function
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis (PubMed:16959576). Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria (PubMed:21285369).
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Uniprot ID
Primary ID:
P49810

Secondarily ID:
A8K8D4
B1AP21
Q96P32
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HGNC ID
HGNC:9509
Subcellular Location
Endoplasmic reticulum membrane
Golgi apparatus membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0003571
 Compound Info 
(4S,4aS,10bS)-10b-(4-chlorophenyl)sulfonyl-7,10-difluoro-4-(2-methylsulfonylethyl)-2,4,4a,5-tetrahydro-1H-pyrano[3,4-c]chromene
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C21H21ClF2O6S2
  1
1
IC50 = 1 nM
 Bioactivity Info 
   TI
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   LO
   TS
CP0008119
 Compound Info 
(4S,4aS,10bS)-10b-(4-chlorophenyl)sulfonyl-4-(2-ethylsulfonylethyl)-7,10-difluoro-2,4,4a,5-tetrahydro-1H-pyrano[3,4-c]chromene
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C22H23ClF2O6S2
  1
1
IC50 = 2 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0499914
 Compound Info 
2-[(4S,4aS,10bS)-10b-(4-chlorophenyl)sulfonyl-7,10-difluoro-2,4,4a,5-tetrahydro-1H-pyrano[3,4-c]chromen-4-yl]ethyl N-methylcarbamate
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C22H22ClF2NO6S
  1
1
IC50 = 6 nM
 Bioactivity Info 
   TI
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CP0498168
 Compound Info 
2-[(4S,4aS,10bS)-10b-(4-chlorophenyl)sulfonyl-7,10-difluoro-2,4,4a,5-tetrahydro-1H-pyrano[3,4-c]chromen-4-yl]ethanol
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C20H19ClF2O5S
  1
1
IC50 = 8 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0436251
 Compound Info 
3-[(4S,4aS,10bS)-10b-(4-chlorophenyl)sulfonyl-7,10-difluoro-2,4,4a,5-tetrahydro-1H-pyrano[3,4-c]chromen-4-yl]propanenitrile
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C21H18ClF2NO4S
  1
1
IC50 = 16 nM
 Bioactivity Info 
   TI
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CP0508204
 Compound Info 
2-[(4S,4aS,10bS)-10b-(4-chlorophenyl)sulfonyl-7,10-difluoro-2,4,4a,5-tetrahydro-1H-pyrano[3,4-c]chromen-4-yl]ethyl N-ethylcarbamate
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C23H24ClF2NO6S
  1
1
IC50 = 20 nM
 Bioactivity Info 
   TI
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Clinical Information about the Protein
Target 1 ( Presenilin 2 (PSEN2) )
Target Type Clinical trial Target
Disease 1 Target-related Disease  1
1 Myalgia [ICD-11: FB56.2]
Clinical Trial Drug(s) 1 Clinical Trial Drug  1
1 (S)-FLURBIPROFEN
 Drug Info 
Preregistration
Myalgia