General Information of the Protein
Protein ID
PT06920
Protein Name
Sodium-dependent phosphate transport protein 2A
Secondarily
Protein Name
Na(+)-dependent phosphate cotransporter 2A
Sodium/phosphate cotransporter 2A
Solute carrier family 34 member 1
Gene Name
SLC34A1
Secondarily
Gene Name
Slc17a2
Sequence
MMSYSERLGGPAVSPLPVRGRHMVHGAAFAYVPSPQVLHRIPGTTTYAISSLSPVALTEHSCPYGEVLECHDPLPAKLAQEEEQKPEPRLSQKLAQVGTKLLKVPLMLGFLYLFVCSLDVLSSAFQLAGGKVAGDIFKDNAILSNPVAGLVVGILVTVLVQSSSTSTSIIVSMVSSGLLEVSSAIPIIMGSNIGTSVTNTIVALMQAGDRTDFRRAFAGATVHDCFNWLSVLVLLPLEAATGYLHHVTGLVVASFNIRGGRDAPDLLKVITEPFTKLIIQLDKSVITSIAVGDESLRNHSLIRIWCQPETKEASTSMSRVEAIGSLANTTMEKCNHIFVDTGLPDLAVGLILLAGSLVVLCTCLILLVKMLNSLLKGQVANVIQKVINTDFPAPFTWVTGYFAMVVGASMTFVVQSSSVFTSAITPLIGLGVISIERAYPLTLGSNIGTTTTAILAALASPREKLSSSFQIALCHFFFNISGILLWYPLPCTRLPIRMAKALGKRTAKYRWFAVLYLLVCFLLLPSLVFGISMAGWQAMVGVGTPFGALLAFVVLVNVLQSRSPGHLPKWLQTWDFLPRWMHSLQPLDGLITRATLCYARPEPRSPQLPPRVFLEELPPATPSPRLALPAHHNATRL
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Organism
Rattus norvegicus, Rat
Protein Classification
Transporter
>
Electrochemical transporter
>
SLC superfamily of solute carriers
>
SLC34 family of sodium phosphate co-transporters
Function
Involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane (PubMed:8327470, PubMed:9058191, PubMed:10198426, PubMed:10370077, PubMed:10926678). The cotransport has a Na(+):Pi stoichiometry of 3:1 and is electrogenic (PubMed:10198426).
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Uniprot ID
Q06496
Ensembl ID
ENSG00000131183
Subcellular Location
Apical cell membrane
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0432155
 Compound Info 
3-chloro-7-[(2S)-2-(hydroxymethyl)morpholin-4-yl]-2-methyl-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile
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C15H14ClF3N4O2
  1
1
IC50 = 400 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT07589 Sodium-dependent phosphate transport protein 2A Mus musculus, Mouse
 Protein Info