General Information of the Protein
Protein ID
PT06906
Protein Name
Solute carrier family 2, facilitated glucose transporter member 8
Secondarily
Protein Name
Glucose transporter type 8
Glucose transporter type X1
Gene Name
SLC2A8
Secondarily
Gene Name
GLUT8
GLUTX1
Sequence
MTPEDPEETQPLLGPPGGSAPRGRRVFLAAFAAALGPLSFGFALGYSSPAIPSLQRAAPPAPRLDDAAASWFGAVVTLGAAAGGVLGGWLVDRAGRKLSLLLCSVPFVAGFAVITAAQDVWMLLGGRLLTGLACGVASLVAPVYISEIAYPAVRGLLGSCVQLMVVVGILLAYLAGWVLEWRWLAVLGCVPPSLMLLLMCFMPETPRFLLTQHRRQEAMAALRFLWGSEQGWEDPPIGAEQSFHLALLRQPGIYKPFIIGVSLMAFQQLSGVNAVMFYAETIFEEAKFKDSSLASVVVGVIQVLFTAVAALIMDRAGRRLLLVLSGVVMVFSTSAFGAYFKLTQGGPGNSSHVAISAPVSAQPVDASVGLAWLAVGSMCLFIAGFAVGWGPIPWLLMSEIFPLHVKGVATGICVLTNWLMAFLVTKEFSSLMEVLRPYGAFWLASAFCIFSVLFTLFCVPETKGKTLEQITAHFEGR
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Organism
Homo sapiens, Human
Protein Classification
Transporter
>
Electrochemical transporter
>
SLC superfamily of solute carriers
>
SLC02 family of hexose and sugar alcohol transporters
Function
Insulin-regulated facilitative hexose transporter that mediates the transport of glucose and fructose (By similarity). Facilitates hepatic influx of dietary trehalose, which in turn inhibits glucose and fructose influx triggering a starvation signal and hepatic autophagy through activation of AMPK and ULK1 (PubMed:27922102). Also able to mediate the transport of dehydroascorbate.
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Uniprot ID
Primary ID:
Q9NY64

Secondarily ID:
Q8WUZ9
Q9NSC4
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Ensembl ID
ENSG00000136856
HGNC ID
HGNC:13812
Subcellular Location
Cell membrane
Cytoplasmic vesicle membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0247656
 Compound Info 
N-[[3-[2-(4-fluorophenyl)ethoxy]phenyl]methyl]-4-methoxy-N-(pyridin-4-ylmethyl)benzamide
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C29H27FN2O3
  1
1
IC50 = 6000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0383538
 Compound Info 
4-methoxy-N-[[3-[(3-methoxyphenyl)methoxy]phenyl]methyl]-N-(pyridin-4-ylmethyl)benzamide
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C29H28N2O4
  1
1
IC50 > 100000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0383539
 Compound Info 
N-[[3-[2-(4-fluorophenyl)ethoxy]phenyl]methyl]-2-(4-methoxyphenyl)-N-(pyridin-4-ylmethyl)acetamide
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C30H29FN2O3
  1
1
IC50 > 100000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0481651
 Compound Info 
3-[(pyridin-4-ylmethylamino)methyl]phenol
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C13H14N2O
  1
1
IC50 > 100000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0247656
 Compound Info 
N-[[3-[2-(4-fluorophenyl)ethoxy]phenyl]methyl]-4-methoxy-N-(pyridin-4-ylmethyl)benzamide
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C29H27FN2O3
  1
1 IC50 = 6000 nM