General Information of the Protein
| Protein ID |
PT06798
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| Protein Name |
Envelope phospholipase OPG057
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| Secondarily Protein Name |
37 kDa protein
Envelope phospholipase F13
Palmitoylated EV membrane protein
p37K
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| Gene Name |
OPG057
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| Secondarily Gene Name |
VACWR052
F13L
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| Sequence |
MWPFASVPAGAKCRLVETLPENMDFRSDHLTTFECFNEIITLAKKYIYIASFCCNPLSTTRGALIFDKLKEASEKGIKIIVLLDERGKRNLGELQSHCPDINFITVNIDKKNNVGLLLGCFWVSDDERCYVGNASFTGGSIHTIKTLGVYSDYPPLATDLRRRFDTFKAFNSAKNSWLNLCSAACCLPVSTAYHIKNPIGGVFFTDSPEHLLGYSRDLDTDVVIDKLKSAKTSIDIEHLAIVPTTRVDGNSYYWPDIYNSIIEAAINRGVKIRLLVGNWDKNDVYSMATARSLDALCVQNDLSVKVFTIQNNTKLLIVDDEYVHITSANFDGTHYQNHGFVSFNSIDKQLVSEAKKIFERDWVSSHSKSLKI
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| Organism |
Vaccinia virus (strain Western Reserve), VACV, Vaccinia virus (strain WR)
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| Protein Classification |
Enzyme
>
Hydrolase
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| Function |
Major envelope protein that plays a role in the biogenesis of the viral double membrane and in egress of virus from the host cell (PubMed:8999886, PubMed:17475658, PubMed:27466413). Produces the wrapped form of virus that is required for cell-to-cell spread (PubMed:27466413, PubMed:29540596). Acts as a lipase with broad specificity including phospholipase C, phospholipase A, and triacylglycerol lipase activities (PubMed:9405398).
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| Uniprot ID |
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| Subcellular Location |
Virion membrane
Host Golgi apparatus
Host trans-Golgi network
Host endoplasmic reticulum membrane
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Map of Molecular Bioactivity Related to the Protein
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Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
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Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000057 , Vero
