General Information of the Protein
Protein ID
PT06777
Protein Name
Protein ADM2
Secondarily
Protein Name
Intermedin
Intermedin-long
Gene Name
ADM2
Secondarily
Gene Name
AM2
Sequence
MARIPTAALGCISLLCLQLPGSLSRSLGGDPRPVKPREPPARSPSSSLQPRHPAPRPVVWKLHRALQAQRGAGLAPVMGQPLRDGGRQHSGPRRHSGPRRTQAQLLRVGCVLGTCQVQNLSHRLWQLMGPAGRQDSAPVDPSSPHSYG
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Organism
Homo sapiens, Human
Protein Classification
Secreted protein
Function
May play a role as physiological regulators of gastrointestinal, cardiovascular bioactivities mediated by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent pathway.
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Uniprot ID
Primary ID:
Q7Z4H4

Secondarily ID:
Q3LFQ0
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HGNC ID
HGNC:28898
Subcellular Location
Secreted
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000094 , 1321N1
Compound ID Compound Name Compound Formula
CP0533804
2,2-dimethyl-N-[[2-(methylaminomethyl)phenyl]methyl]-N-[2-oxo-2-[(2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl)amino]ethyl]propanamide
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C31H35N5O3
 1
1
IC50 = 0.631 nM
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CP0549140
N-[[2-[(cyclopropylamino)methyl]phenyl]methyl]-2,2-dimethyl-N-[2-oxo-2-[(2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl)amino]ethyl]propanamide
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C33H37N5O3
 1
1
IC50 = 1 nM
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CP0572344
N-[[2-(azetidin-1-ylmethyl)phenyl]methyl]-2,2-dimethyl-N-[2-oxo-2-[(2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl)amino]ethyl]propanamide
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C33H37N5O3
 1
1
IC50 = 1.585 nM
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CP0572345
N-[[2-(1-aminoethyl)phenyl]methyl]-2,2-dimethyl-N-[2-oxo-2-[(2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl)amino]ethyl]propanamide
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C31H35N5O3
 1
1
IC50 = 5.012 nM
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CP0507382
N-[(2-aminophenyl)methyl]-2,2-dimethyl-N-[2-oxo-2-[(2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl)amino]ethyl]propanamide
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C29H31N5O3
 1
1
IC50 = 6.31 nM
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CP0546386
N-[[2-(aminomethyl)phenyl]methyl]-2,2-dimethyl-N-[2-oxo-2-[(2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl)amino]ethyl]propanamide
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C30H33N5O3
 1
1
IC50 = 7.943 nM
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CP0549141
N-[[2-(2-aminoethyl)phenyl]methyl]-2,2-dimethyl-N-[2-oxo-2-[(2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl)amino]ethyl]propanamide
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C31H35N5O3
 1
1
IC50 = 31.62 nM
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CP0531177
2-[[2,2-dimethylpropanoyl-[2-oxo-2-[(2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl)amino]ethyl]amino]methyl]benzamide
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C30H31N5O4
 1
1
IC50 = 79.43 nM
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CP0418498
N-[[2-[(diaminomethylideneamino)methyl]phenyl]methyl]-2,2-dimethyl-N-[2-oxo-2-[(2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl)amino]ethyl]propanamide
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C31H35N7O3
 1
1
IC50 = 100 nM
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CP0558401
2,2-dimethyl-N-[2-oxo-2-[(2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl)amino]ethyl]-N-(1,2,3,4-tetrahydroisoquinolin-8-ylmethyl)propanamide
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C32H35N5O3
 1
1
IC50 = 100 nM
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CP0507380
N-[[2-(hydroxymethyl)phenyl]methyl]-2,2-dimethyl-N-[2-oxo-2-[(2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl)amino]ethyl]propanamide
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C30H32N4O4
 1
1
IC50 = 125.89 nM
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CP0558402
N-[[2-(imidazol-1-ylmethyl)phenyl]methyl]-2,2-dimethyl-N-[2-oxo-2-[(2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl)amino]ethyl]propanamide
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C33H34N6O3
 1
1
IC50 = 125.89 nM
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CP0569998
N-benzyl-2,2-dimethyl-N-[2-oxo-2-[(2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl)amino]ethyl]propanamide
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C29H30N4O3
 1
1
IC50 = 199.53 nM
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CP0418495
2,2-dimethyl-N-[2-oxo-2-[(2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl)amino]ethyl]-N-[(2-pyrrolidin-3-ylphenyl)methyl]propanamide
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C33H37N5O3
 1
1
IC50 = 316.23 nM
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CP0959215
N-((1H-Indozol-4-yl)methyl)-N-(2-oxo-2-((2'-oxo-1,1',2',3-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-5-yl)amino)-ethyl)pivalamide
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C30H30N6O3
 1
1
IC50 = 316.23 nM
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CP0546385
N-[(2-cyanophenyl)methyl]-2,2-dimethyl-N-[2-oxo-2-[(2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl)amino]ethyl]propanamide
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C30H29N5O3
 1
1
IC50 = 501.19 nM
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CP0507383
N-[1-[2-(aminomethyl)phenyl]ethyl]-2,2-dimethyl-N-[2-oxo-2-[(2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl)amino]ethyl]propanamide
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C31H35N5O3
 1
1
IC50 = 794.33 nM
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CP0546384
2,2-dimethyl-N-[2-oxo-2-[(2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl)amino]ethyl]-N-[(2-pyridin-3-ylphenyl)methyl]propanamide
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C34H33N5O3
 1
1
IC50 = 1000 nM
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CP0549138
2,2-dimethyl-N-[2-oxo-2-[(2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl)amino]ethyl]-N-(pyridin-2-ylmethyl)propanamide
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C28H29N5O3
 1
1
IC50 = 1000 nM
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CP0551838
2,2-dimethyl-N-[2-oxo-2-[(2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl)amino]ethyl]-N-(1,3-thiazol-2-ylmethyl)propanamide
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C26H27N5O3S
 1
1
IC50 = 1000 nM
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CP0418497
2,2-dimethyl-N-[[2-(morpholin-4-ylmethyl)phenyl]methyl]-N-[2-oxo-2-[(2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl)amino]ethyl]propanamide
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C34H39N5O4
 1
1
IC50 = 1258.93 nM
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CP0507379
N-benzyl-2,2-dimethyl-N-[2-[(1'-methyl-2',4'-dioxospiro[1,3-dihydroindene-2,5'-imidazolidine]-5-yl)amino]-2-oxoethyl]propanamide
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C26H30N4O4
 1
1
IC50 = 1258.93 nM
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CP0507381
N-[[3-(aminomethyl)pyridin-2-yl]methyl]-2,2-dimethyl-N-[2-oxo-2-[(2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl)amino]ethyl]propanamide
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C29H32N6O3
 1
1
IC50 = 1995.26 nM
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CP0418496
N-[[3-(aminomethyl)phenyl]methyl]-2,2-dimethyl-N-[2-oxo-2-[(2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl)amino]ethyl]propanamide
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C30H33N5O3
 1
1
IC50 = 3162.28 nM
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CP0558403
2,2-dimethyl-N-[2-oxo-2-[(2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl)amino]ethyl]-N-[(2-phenylpyrazol-3-yl)methyl]propanamide
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C32H32N6O3
 1
1
IC50 = 7943.28 nM
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CP0533803
N-benzyl-2,2-dimethyl-N-[2-oxo-2-[4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidin-1-yl]ethyl]propanamide
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C25H31N5O3
 1
1
IC50 > 10000 nM
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CP0551837
N-benzyl-2,2-dimethyl-N-[2-oxo-2-[4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidin-1-yl]ethyl]propanamide
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C27H34N4O3
 1
1
IC50 > 10000 nM
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CP0572343
2,2-dimethyl-N-[(1-methylpiperidin-3-yl)methyl]-N-[2-oxo-2-[(2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl)amino]ethyl]propanamide
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C29H37N5O3
 1
1
IC50 > 10000 nM
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Clinical Information about the Protein
Target 1 ( Adrenomedullin 2 (ADM2) )
Target Type Literature-reported Target