General Information of the Protein
Protein ID
PT06723
Protein Name
DNA repair protein complementing XP-A cells
Secondarily
Protein Name
Xeroderma pigmentosum group A-complementing protein
Gene Name
XPA
Secondarily
Gene Name
XPAC
Sequence
MAAADGALPEAAALEQPAELPASVRASIERKRQRALMLRQARLAARPYSATAAAATGGMANVKAAPKIIDTGGGFILEEEEEEEQKIGKVVHQPGPVMEFDYVICEECGKEFMDSYLMNHFDLPTCDNCRDADDKHKLITKTEAKQEYLLKDCDLEKREPPLKFIVKKNPHHSQWGDMKLYLKLQIVKRSLEVWGSQEALEEAKEVRQENREKMKQKKFDKKVKELRRAVRSSVWKRETIVHQHEYGPEENLEDDMYRKTCTMCGHELTYEKM
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Organism
Homo sapiens, Human
Protein Classification
Other nuclear protein
Function
Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation.
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Uniprot ID
Primary ID:
P23025

Secondarily ID:
Q5T1U9
Q6LCW7
Q6LD02
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Ensembl ID
ENSG00000136936
HGNC ID
HGNC:12814
Subcellular Location
Nucleus
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000013 , Sf9
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0468733
 Compound Info 
2-chloro-5-[(4Z)-4-[[5-(4-chloro-3-phenylmethoxycarbonylphenyl)furan-2-yl]methylidene]-3-methyl-5-oxopyrazol-1-yl]benzoic acid
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C30H20Cl2N2O6
  1
1
IC50 = 820 nM
 Bioactivity Info 
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CP0455593
 Compound Info 
2-chloro-5-[(4Z)-4-[[5-[4-chloro-3-[(2-chlorophenyl)methoxycarbonyl]phenyl]furan-2-yl]methylidene]-3-methyl-5-oxopyrazol-1-yl]benzoic acid
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C30H19Cl3N2O6
  1
1
IC50 = 1300 nM
 Bioactivity Info 
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CP0574135
 Compound Info 
2-chloro-5-[(4Z)-3-methyl-5-oxo-4-[[5-(3-propan-2-yloxycarbonylphenyl)furan-2-yl]methylidene]pyrazol-1-yl]benzoic acid
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C26H21ClN2O6
  1
1
IC50 = 1600 nM
 Bioactivity Info 
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CP0563497
 Compound Info 
3-[(4Z)-4-[[5-[4-chloro-3-[(2-chlorophenyl)methoxycarbonyl]phenyl]furan-2-yl]methylidene]-3-methyl-5-oxopyrazol-1-yl]benzoic acid
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C30H20Cl2N2O6
  1
1
IC50 = 1930 nM
 Bioactivity Info 
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CP0454563
 Compound Info 
3-[(4Z)-4-[[5-(4-chloro-3-ethoxycarbonylphenyl)furan-2-yl]methylidene]-3-methyl-5-oxopyrazol-1-yl]benzoic acid
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C25H19ClN2O6
  1
1
IC50 = 4820 nM
 Bioactivity Info 
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CP0561317
 Compound Info 
2-chloro-5-[(4Z)-4-[[5-(3-ethoxycarbonylphenyl)furan-2-yl]methylidene]-3-methyl-5-oxopyrazol-1-yl]benzoic acid
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C25H19ClN2O6
  1
1
IC50 = 5230 nM
 Bioactivity Info 
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CP0552631
 Compound Info 
2-chloro-5-[(4Z)-4-[[5-(4-chloro-3-prop-2-enoxycarbonylphenyl)furan-2-yl]methylidene]-3-methyl-5-oxopyrazol-1-yl]benzoic acid
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C26H18Cl2N2O6
  1
1
IC50 = 6800 nM
 Bioactivity Info 
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CP0413039
 Compound Info 
4-[(4Z)-4-[[5-[4-chloro-3-[(4-fluorophenyl)methylcarbamoyl]phenyl]furan-2-yl]methylidene]-3-methyl-5-oxopyrazol-1-yl]benzoic acid
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C30H21ClFN3O5
  1
1
IC50 = 8400 nM
 Bioactivity Info 
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CP0454561
 Compound Info 
3-[(4Z)-4-[[5-(3-butoxycarbonyl-4-chlorophenyl)furan-2-yl]methylidene]-3-methyl-5-oxopyrazol-1-yl]benzoic acid
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C27H23ClN2O6
  1
1
IC50 = 9100 nM
 Bioactivity Info 
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CP0468732
 Compound Info 
4-[(4Z)-4-[[5-[4-chloro-3-(cyclopropylmethylcarbamoyl)phenyl]furan-2-yl]methylidene]-3-methyl-5-oxopyrazol-1-yl]benzoic acid
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C27H22ClN3O5
  1
1
IC50 = 9100 nM
 Bioactivity Info 
   TI
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CP0574597
 Compound Info 
4-[(4Z)-4-[[5-[4-[(4-fluorophenyl)methylcarbamoyl]phenyl]furan-2-yl]methylidene]-3-methyl-5-oxopyrazol-1-yl]benzoic acid
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C30H22FN3O5
  1
1
IC50 = 9100 nM
 Bioactivity Info 
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CP0471111
 Compound Info 
5-[(4Z)-4-[[5-(3-butoxycarbonyl-4-chlorophenyl)furan-2-yl]methylidene]-3-methyl-5-oxopyrazol-1-yl]-2-chlorobenzoic acid
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C27H22Cl2N2O6
  1
1
IC50 = 9600 nM
 Bioactivity Info 
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CP0561320
 Compound Info 
3-[(4Z)-4-[[5-[4-chloro-3-(cyclopropylmethylcarbamoyl)phenyl]furan-2-yl]methylidene]-3-methyl-5-oxopyrazol-1-yl]benzoic acid
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C27H22ClN3O5
  1
1
IC50 = 9800 nM
 Bioactivity Info 
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CP0455591
 Compound Info 
3-[(4Z)-4-[[5-(3-methoxycarbonylphenyl)furan-2-yl]methylidene]-5-oxo-3-(trifluoromethyl)pyrazol-1-yl]benzoic acid
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C24H15F3N2O6
  1
1
IC50 = 11500 nM
 Bioactivity Info 
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CP0561319
 Compound Info 
3-[(4Z)-4-[[5-[4-chloro-3-[(3,4-dimethoxyphenyl)carbamoyl]phenyl]furan-2-yl]methylidene]-3-methyl-5-oxopyrazol-1-yl]benzoic acid
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C31H24ClN3O7
  1
1
IC50 = 11700 nM
 Bioactivity Info 
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CP0458628
 Compound Info 
4-[(4Z)-4-[[5-[4-chloro-3-[(3-methoxyphenyl)carbamoyl]phenyl]furan-2-yl]methylidene]-3-methyl-5-oxopyrazol-1-yl]benzoic acid
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C30H22ClN3O6
  1
1
IC50 = 11900 nM
 Bioactivity Info 
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CP0461843
 Compound Info 
3-[(4Z)-4-[[5-[4-chloro-3-[(4-fluorophenyl)methylcarbamoyl]phenyl]furan-2-yl]methylidene]-3-methyl-5-oxopyrazol-1-yl]benzoic acid
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C30H21ClFN3O5
  1
1
IC50 = 12000 nM
 Bioactivity Info 
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CP0544811
 Compound Info 
3-[(4Z)-4-[[5-(2-methoxy-4-nitrophenyl)furan-2-yl]methylidene]-3-methyl-5-oxopyrazol-1-yl]benzoic acid
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C23H17N3O7
  1
1
IC50 = 12000 nM
 Bioactivity Info 
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CP0507091
 Compound Info 
3-[(4Z)-4-[[5-(4-chloro-3-propoxycarbonylphenyl)furan-2-yl]methylidene]-3-methyl-5-oxopyrazol-1-yl]benzoic acid
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C26H21ClN2O6
  1
1
IC50 = 12600 nM
 Bioactivity Info 
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CP0460458
 Compound Info 
3-[(4Z)-4-[[5-(2-bromo-4-nitrophenyl)furan-2-yl]methylidene]-3-methyl-5-oxopyrazol-1-yl]benzoic acid
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C22H14BrN3O6
  1
1
IC50 = 13100 nM
 Bioactivity Info 
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CP0567229
 Compound Info 
4-[(4Z)-4-[[5-[4-(cyclopropylmethylcarbamoyl)phenyl]furan-2-yl]methylidene]-3-methyl-5-oxopyrazol-1-yl]benzoic acid
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C27H23N3O5
  1
1
IC50 = 13400 nM
 Bioactivity Info 
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CP0561321
 Compound Info 
3-[(4Z)-4-[[5-[4-chloro-3-[(3-methoxyphenyl)carbamoyl]phenyl]furan-2-yl]methylidene]-3-methyl-5-oxopyrazol-1-yl]benzoic acid
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C30H22ClN3O6
  1
1
IC50 = 14100 nM
 Bioactivity Info 
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CP0544812
 Compound Info 
3-[(4Z)-4-[[5-[4-chloro-3-(oxan-4-ylmethylcarbamoyl)phenyl]furan-2-yl]methylidene]-3-methyl-5-oxopyrazol-1-yl]benzoic acid
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C29H26ClN3O6
  1
1
IC50 = 14300 nM
 Bioactivity Info 
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CP0552630
 Compound Info 
5-[(4Z)-4-[[5-(2-bromo-4-nitrophenyl)furan-2-yl]methylidene]-3-methyl-5-oxopyrazol-1-yl]-2-chlorobenzoic acid
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C22H13BrClN3O6
  1
1
IC50 = 17800 nM
 Bioactivity Info 
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CP0455594
 Compound Info 
ethyl 3-[(4Z)-4-[[5-[4-chloro-3-[(4-fluorophenyl)methylcarbamoyl]phenyl]furan-2-yl]methylidene]-3-methyl-5-oxopyrazol-1-yl]benzoate
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C32H25ClFN3O5
  1
1
IC50 > 25000 nM
 Bioactivity Info 
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CP0944465
 Compound Info 
(Z)-3-(4-((5-(4-Chloro-3-((tetrahydro-2H-pyran-4-yl)carbamoyl)-phenyl)furan-2-yl)methylene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic Acid
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C28H24ClN3O6
  1
1
IC50 >= 25000 nM
 Bioactivity Info 
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CP0963813
 Compound Info 
(Z)-3-(4-((5-(4-Chloro-3-(cyclopropylcarbamoyl)phenyl)furan-2-yl)methylene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic Acid
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C26H20ClN3O5
  1
1
IC50 >= 25000 nM
 Bioactivity Info 
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CP0413040
 Compound Info 
5-[5-[(Z)-[1-(3-carboxyphenyl)-3-methyl-5-oxopyrazol-4-ylidene]methyl]furan-2-yl]-2-chlorobenzoic acid
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C23H15ClN2O6
  1
1
IC50 > 50000 nM
 Bioactivity Info 
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CP0455592
 Compound Info 
2-[5-[(Z)-[1-(3-carboxyphenyl)-3-methyl-5-oxopyrazol-4-ylidene]methyl]furan-2-yl]benzoic acid
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C23H16N2O6
  1
1
IC50 > 50000 nM
 Bioactivity Info 
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CP0455595
 Compound Info 
3-[(4Z)-4-[[5-[4-[(4-fluorophenyl)methylcarbamoyl]phenyl]furan-2-yl]methylidene]-3-methyl-5-oxopyrazol-1-yl]benzoic acid
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C30H22FN3O5
  1
1
IC50 > 50000 nM
 Bioactivity Info 
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CP0468731
 Compound Info 
3-[(4Z)-4-[[5-(4-carboxyphenyl)furan-2-yl]methylidene]-3-methyl-5-oxopyrazol-1-yl]benzoic acid
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C23H16N2O6
  1
1
IC50 > 50000 nM
 Bioactivity Info 
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CP0479650
 Compound Info 
2-chloro-N-(cyclopropylmethyl)-5-[5-[(Z)-[1-[3-(cyclopropylmethylcarbamoyl)phenyl]-3-methyl-5-oxopyrazol-4-ylidene]methyl]furan-2-yl]benzamide
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C31H29ClN4O4
  1
1
IC50 > 50000 nM
 Bioactivity Info 
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CP0547885
 Compound Info 
3-[(4Z)-4-[[5-[4-(cyclopropylmethylcarbamoyl)phenyl]furan-2-yl]methylidene]-3-methyl-5-oxopyrazol-1-yl]benzoic acid
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C27H23N3O5
  1
1
IC50 > 50000 nM
 Bioactivity Info 
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CP0558323
 Compound Info 
3-[5-[(Z)-[1-(3-carboxyphenyl)-3-methyl-5-oxopyrazol-4-ylidene]methyl]furan-2-yl]benzoic acid
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C23H16N2O6
  1
1
IC50 > 50000 nM
 Bioactivity Info 
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Clinical Information about the Protein
Target 1 ( DNA repair protein complementing XP-A cells (XPA) )
Target Type Literature-reported Target