General Information of the Protein
Protein ID
PT06722
Protein Name
Zinc finger and BTB domain-containing protein 16
Secondarily
Protein Name
Promyelocytic leukemia zinc finger protein
Zinc finger protein 145
Zinc finger protein PLZF
Gene Name
ZBTB16
Secondarily
Gene Name
PLZF
ZNF145
Sequence
MDLTKMGMIQLQNPSHPTGLLCKANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFEILFHRNSQHYTLDFLSPKTFQQILEYAYTATLQAKAEDLDDLLYAAEILEIEYLEEQCLKMLETIQASDDNDTEATMADGGAEEEEDRKARYLKNIFISKHSSEESGYASVAGQSLPGPMVDQSPSVSTSFGLSAMSPTKAAVDSLMTIGQSLLQGTLQPPAGPEEPTLAGGGRHPGVAEVKTEMMQVDEVPSQDSPGAAESSISGGMGDKVEERGKEGPGTPTRSSVITSARELHYGREESAEQVPPPAEAGQAPTGRPEHPAPPPEKHLGIYSVLPNHKADAVLSMPSSVTSGLHVQPALAVSMDFSTYGGLLPQGFIQRELFSKLGELAVGMKSESRTIGEQCSVCGVELPDNEAVEQHRKLHSGMKTYGCELCGKRFLDSLRLRMHLLAHSAGAKAFVCDQCGAQFSKEDALETHRQTHTGTDMAVFCLLCGKRFQAQSALQQHMEVHAGVRSYICSECNRTFPSHTALKRHLRSHTGDHPYECEFCGSCFRDESTLKSHKRIHTGEKPYECNGCGKKFSLKHQLETHYRVHTGEKPFECKLCHQRSRDYSAMIKHLRTHNGASPYQCTICTEYCPSLSSMQKHMKGHKPEEIPPDWRIEKTYLYLCYV
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Organism
Homo sapiens, Human
Protein Classification
Transcription factor
Function
Acts as a transcriptional repressor (PubMed:10688654, PubMed:24359566). Transcriptional repression may be mediated through recruitment of histone deacetylases to target promoters (PubMed:10688654). May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312).
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Uniprot ID
Primary ID:
Q05516

Secondarily ID:
Q8TAL4
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Ensembl ID
ENSG00000109906
HGNC ID
HGNC:12930
Subcellular Location
Nucleus
Nucleus
Nuclear body
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000314 , HEK293T/17
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0331609
 Compound Info 
(12S,14S,17E)-23-benzyl-7-chloro-12-(hydroxymethyl)-15,20-dioxa-2,4,5,9,11,23-hexazahexacyclo[19.7.1.13,10.111,14.04,8.022,27]hentriaconta-1(28),3(31),5,7,9,17,21(29),22(27)-octaen-24-one
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C31H31ClN6O4
  1
1
IC50 > 30000 nM
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CP0393891
 Compound Info 
(12S,14S,17E)-12-(hydroxymethyl)-23-[(3-methoxyphenyl)methyl]-24-oxo-15,20-dioxa-2,4,5,9,11,23-hexazahexacyclo[19.7.1.13,10.111,14.04,8.022,27]hentriaconta-1(28),3(31),5,7,9,17,21(29),22(27)-octaene-7-carbonitrile
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C33H33N7O5
  1
1
IC50 > 30000 nM
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CP0412952
 Compound Info 
(12S,14S,17E)-7-chloro-12-(hydroxymethyl)-23-[(3-methoxyphenyl)methyl]-15,20-dioxa-2,4,5,9,11,23-hexazahexacyclo[19.7.1.13,10.111,14.04,8.022,27]hentriaconta-1(28),3(31),5,7,9,17,21(29),22(27)-octaen-24-one
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C32H33ClN6O5
  1
1
IC50 > 30000 nM
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CP0446898
 Compound Info 
(12S,14S,17E)-7-chloro-23-(cyclopropylmethyl)-12-(hydroxymethyl)-15,20-dioxa-2,4,5,9,11,23-hexazahexacyclo[19.7.1.13,10.111,14.04,8.022,27]hentriaconta-1(28),3(31),5,7,9,17,21(29),22(27)-octaen-24-one
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C28H31ClN6O4
  1
1
IC50 > 30000 nM
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CP0461715
 Compound Info 
(12S,14S,17E)-7-chloro-12-(hydroxymethyl)-15,20-dioxa-2,4,5,9,11,23-hexazahexacyclo[19.7.1.13,10.111,14.04,8.022,27]hentriaconta-1(28),3(31),5,7,9,17,21(29),22(27)-octaen-24-one
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C24H25ClN6O4
  1
1
IC50 > 30000 nM
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CP0461716
 Compound Info 
(12S,14S,17E)-7-chloro-12-(hydroxymethyl)-23-[(4-methylphenyl)methyl]-15,20-dioxa-2,4,5,9,11,23-hexazahexacyclo[19.7.1.13,10.111,14.04,8.022,27]hentriaconta-1(28),3(31),5,7,9,17,21(29),22(27)-octaen-24-one
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C32H33ClN6O4
  1
1
IC50 > 30000 nM
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CP0461746
 Compound Info 
(12S,14S,17E)-7-chloro-23-[(3,3-difluorocyclobutyl)methyl]-12-(hydroxymethyl)-15,20-dioxa-2,4,5,9,11,23-hexazahexacyclo[19.7.1.13,10.111,14.04,8.022,27]hentriaconta-1(28),3(31),5,7,9,17,21(29),22(27)-octaen-24-one
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C29H31ClF2N6O4
  1
1
IC50 > 30000 nM
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CP0469977
 Compound Info 
(12S,14S)-12-(hydroxymethyl)-15,20-dioxa-2,4,5,9,11,23-hexazahexacyclo[19.7.1.13,10.111,14.04,8.022,27]hentriaconta-1(28),3(31),5,7,9,21(29),22(27)-heptaen-24-one
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C24H28N6O4
  1
1
IC50 > 30000 nM
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CP0472404
 Compound Info 
(14S)-24-oxo-15,20-dioxa-2,4,5,9,11,23-hexazahexacyclo[19.7.1.13,10.111,14.04,8.022,27]hentriaconta-1(28),3(31),5,7,9,21(29),22(27)-heptaene-7-carbonitrile
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C24H25N7O3
  1
1
IC50 > 30000 nM
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CP0508447
 Compound Info 
2-[(12S,14S,17E)-7-chloro-23-[(3,3-difluorocyclobutyl)methyl]-24-oxo-15,20-dioxa-2,4,5,9,11,23-hexazahexacyclo[19.7.1.13,10.111,14.04,8.022,27]hentriaconta-1(28),3(31),5,7,9,17,21(29),22(27)-octaen-12-yl]acetic acid
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C30H31ClF2N6O5
  1
1
IC50 > 30000 nM
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CP0519940
 Compound Info 
(12S,14S)-12-(hydroxymethyl)-24-oxo-15,20-dioxa-2,4,5,9,11,23-hexazahexacyclo[19.7.1.13,10.111,14.04,8.022,27]hentriaconta-1(28),3(31),5,7,9,21(29),22(27)-heptaene-7-carbonitrile
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C25H27N7O4
  1
1
IC50 > 30000 nM
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CP0521736
 Compound Info 
(12S,14S,17E)-7-chloro-12-(hydroxymethyl)-23-methyl-15,20-dioxa-2,4,5,9,11,23-hexazahexacyclo[19.7.1.13,10.111,14.04,8.022,27]hentriaconta-1(28),3(31),5,7,9,17,21(29),22(27)-octaen-24-one
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C25H27ClN6O4
  1
1
IC50 > 30000 nM
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CP0521737
 Compound Info 
(12S,14S,17E)-7-chloro-12-(hydroxymethyl)-23-[(2-methylphenyl)methyl]-15,20-dioxa-2,4,5,9,11,23-hexazahexacyclo[19.7.1.13,10.111,14.04,8.022,27]hentriaconta-1(28),3(31),5,7,9,17,21(29),22(27)-octaen-24-one
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C32H33ClN6O4
  1
1
IC50 > 30000 nM
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CP0543050
 Compound Info 
(12S,14S,17E)-12-(hydroxymethyl)-24-oxo-15,20-dioxa-2,4,5,9,11,23-hexazahexacyclo[19.7.1.13,10.111,14.04,8.022,27]hentriaconta-1(28),3(31),5,7,9,17,21(29),22(27)-octaene-7-carbonitrile
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C25H25N7O4
  1
1
IC50 > 30000 nM
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CP0544259
 Compound Info 
(12S,14S,17E)-7-chloro-12-(hydroxymethyl)-23-(3-morpholin-4-ylpropyl)-15,20-dioxa-2,4,5,9,11,23-hexazahexacyclo[19.7.1.13,10.111,14.04,8.022,27]hentriaconta-1(28),3(31),5,7,9,17,21(29),22(27)-octaen-24-one
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C31H38ClN7O5
  1
1
IC50 > 30000 nM
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CP0544260
 Compound Info 
(12S,14S)-7-chloro-12-(hydroxymethyl)-15,20-dioxa-2,4,5,9,11,23-hexazahexacyclo[19.7.1.13,10.111,14.04,8.022,27]hentriaconta-1(28),3(31),5,7,9,21(29),22(27)-heptaen-24-one
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C24H27ClN6O4
  1
1
IC50 > 30000 nM
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CP0558756
 Compound Info 
(12S,14S,17E)-7-chloro-12-(hydroxymethyl)-23-(pyridin-4-ylmethyl)-15,20-dioxa-2,4,5,9,11,23-hexazahexacyclo[19.7.1.13,10.111,14.04,8.022,27]hentriaconta-1(28),3(31),5,7,9,17,21(29),22(27)-octaen-24-one
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C30H30ClN7O4
  1
1
IC50 > 30000 nM
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