General Information of the Protein
Protein ID
PT06712
Protein Name
Uracil-DNA glycosylase
Gene Name
OPG116
Secondarily
Gene Name
UNG
D4R
Sequence
MNSVTVSHAPYTITYHDDWEPVMSQLVEFYNEVASWLLRDETSPIPDKFFIQLKQPLRNKRVCVCGIDPYPKDGTGVPFESPNFTKKSIKEIASSISRLTGVIDYKGYNLNIIDGVIPWNYYLSCKLGETKSHAIYWDKISKLLLQHITKHVSVLYCLGKTDFSNIRAKLESPVTTIVGYHPAARDRQFEKDRSFEIINVLLELDNKVPINWAQGFIY
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Organism
Vaccinia virus (strain Copenhagen), VACV
Protein Classification
Enzyme
>
Hydrolase
Function
Plays an essential role in viral replication as a component of the DNA polymerase processivity factor (PubMed:24603707). Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (PubMed:26045555).
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Uniprot ID
P20536
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000669 , BS-C-1
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0514973
 Compound Info 
3-(3-((3,5-Dichlorophenyl)thio)-6-methyl-1H-indol-2-yl)propanamide
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C17H14Cl2N2OS
  1
1
IC50 = 42 nM
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CP0518149
 Compound Info 
2-(3-((3,5-Dichlorophenyl)thio)-6-methyl-1H-indol-2-yl)acetamide
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C16H12Cl2N2OS
  1
1
IC50 = 46 nM
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CP0557487
 Compound Info 
4-(3-((3,5-Dichlorophenyl)thio)-6-methyl-1H-indol-2-yl)butanamide
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C19H18Cl2N2OS
  1
1
IC50 = 208 nM
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CP0412328
 Compound Info 
3-(3-((3,5-Dichlorophenyl)thio)-6-methyl-1H-indol-2-yl)propanoic acid
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C18H16Cl2N2OS
  1
1
IC50 = 244 nM
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CP0414193
 Compound Info 
3-((3,5-Dichlorophenyl)thio)-6-methyl-1H-indole-2-carboxylic acid
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C16H11Cl2NO2S
  1
1
IC50 = 7000 nM
 Bioactivity Info 
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CP0419902
 Compound Info 
3-((3,5-Dichlorophenyl)thio)-6-ethyl-1H-indole-2-carboxylic acid
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C17H13Cl2NO2S
  1
1
IC50 = 9000 nM
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CP0557486
 Compound Info 
6-Methyl-3-(phenylthio)-1H-indole-2-carboxylate
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C17H15NO2S
  1
1
IC50 = 10000 nM
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CP0531123
 Compound Info 
4-Methyl-3-((2,4,5-trichlorophenyl)thio)-1H-indole-2-carboxylic acid
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C16H10Cl3NO2S
  1
1
IC50 = 18000 nM
 Bioactivity Info 
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CP0518147
 Compound Info 
Methyl 3-((4-chlorophenyl)thio)-6-methyl-1H-indole-2-carboxylate
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C17H14ClNO2S
  1
1
IC50 = 19000 nM
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CP0530544
 Compound Info 
Methyl 3-((4-chlorophenyl)thio)-4-methyl-1H-indole-2-carboxylate
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C17H14ClNO2S
  1
1
IC50 = 21000 nM
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CP0531122
 Compound Info 
7-Methyl-3-((2,4,5-trichlorophenyl)thio)-1H-indole-2-carboxylic acid
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C16H10Cl3NO2S
  1
1
IC50 = 21000 nM
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CP0555229
 Compound Info 
Methyl 3-((4-chlorophenyl)thio)-7-methyl-1H-indole-2-carboxylate
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C17H14ClNO2S
  1
1
IC50 = 23000 nM
 Bioactivity Info 
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CP0419904
 Compound Info 
6-Methyl-3-((2,4,5-trichlorophenyl)thio)-1H-indole-2-carboxylic acid
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C16H10Cl3NO2S
  1
1
IC50 = 25000 nM
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CP0557485
 Compound Info 
6-Methyl-3-((4-(trifluoromethyl)phenyl)thio)-1H-indole-2-carboxylic acid
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C17H12F3NO2S
  1
1
IC50 = 33000 nM
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CP0531121
 Compound Info 
3-((3,4-Dichlorophenyl)thio)-6-methyl-1H-indole-2-carboxylic acid
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C16H11Cl2NO2S
  1
1
IC50 = 34000 nM
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CP0530546
 Compound Info 
3-((3,4-Dichlorophenyl)thio)-7-methyl-1H-indole-2-carboxylic acid
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C16H11Cl2NO2S
  1
1
IC50 = 35000 nM
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CP0514970
 Compound Info 
3-((4-Chlorophenyl)thio)-6-ethyl-1H-indole-2-carboxylic acid
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C17H14ClNO2S
  1
1
IC50 = 36000 nM
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CP0518148
 Compound Info 
3-((2,4-Dichlorophenyl)thio)-6-methyl-1H-indole-2-carboxylic acid
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C16H11Cl2NO2S
  1
1
IC50 = 37000 nM
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CP0557484
 Compound Info 
Methyl 3-((4-chlorophenyl)thio)-1-ethyl-5-methyl-1H-indole-2-carboxylate
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C19H18ClNO2S
  1
1
IC50 = 39000 nM
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CP0557482
 Compound Info 
6-Fluoro-3-((4-chlorophenyl)thio)-1H-indole-2-carboxylic acid
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C15H9ClFNO2S
  1
1
IC50 = 40000 nM
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CP0514972
 Compound Info 
3-((3,4-Dichlorophenyl)thio)-6-ethyl-1H-indole-2-carboxylic acid
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C17H13Cl2NO2S
  1
1
IC50 = 42000 nM
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CP0419903
 Compound Info 
3-((3,5-Dichlorophenyl)thio)-1H-indole-2-carboxylic acid
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C15H9Cl2NO2S
  1
1
IC50 = 43000 nM
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CP0419901
 Compound Info 
3-((4-Chlorophenyl)thio)-5-methyl-1H-indole-2-carboxylic acid
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C16H12ClNO2S
  1
1
IC50 = 46000 nM
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CP0521559
 Compound Info 
6-Chloro-3-((4-chlorophenyl)thio)-1H-indole-2-carboxylic acid
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C15H9Cl2NO2S
  1
1
IC50 = 47000 nM
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CP0531120
 Compound Info 
3-((4-chlorophenyl)thio)-4,7-dimethyl-1H-indole-2-carboxylic acid
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C17H14ClNO2S
  1
1
IC50 = 50000 nM
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CP0449981
 Compound Info 
3-((3-Chlorophenyl)thio)-6-methyl-1H-indole-2-carboxylic acid
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C16H12ClNO2S
  1
1
IC50 = 51000 nM
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CP0483979
 Compound Info 
6-Bromo-3-((4-chlorophenyl)thio)-1H-indole-2-carboxylic acid
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C15H9BrClNO2S
  1
1
IC50 = 51000 nM
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CP0530545
 Compound Info 
3-((3-Fluorophenyl)thio)-6-methyl-1H-indole-2-carboxylic acid
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C16H12FNO2S
  1
1
IC50 = 69000 nM
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CP0412326
 Compound Info 
3-((4-Chlorophenyl)thio)-7-methyl-1H-indole-2-carboxylic acid
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C16H12ClNO2S
  1
1
IC50 = 74000 nM
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CP0531119
 Compound Info 
US9211296, Table 6, 11
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C16H12ClNO2S
  1
1
IC50 = 82000 nM
 Bioactivity Info 
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CP0557483
 Compound Info 
3-((4-Chlorophenyl)thio)-1-ethyl-5-methyl-1H-indole-2-carboxylic acid
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C18H16ClNO2S
  1
1
IC50 = 86000 nM
 Bioactivity Info 
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CP0569079
 Compound Info 
3-((4-Chlorophenyl)thio)-4-methyl-1H-indole-2-carboxylic acid
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C16H12ClNO2S
  1
1
IC50 = 86000 nM
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