General Information of the Protein
Protein ID
PT06668
Protein Name
5-hydroxytryptamine receptor 1B
Secondarily
Protein Name
Serotonin receptor 1B
Gene Name
HTR1B
Sequence
MEEPGAQCAPPXPAGSETWVPQANLSSAPSQNCSAKDYIYQDSIALPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCTS
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Organism
Gorilla gorilla gorilla, Western lowland gorilla
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Serotonin receptor
Function
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries (By similarity).
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Uniprot ID
Q9N2B7
Ensembl ID
ENSG00000135312
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0005653
 Compound Info 
(3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methylmethanesulfonamide
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C14H21N3O2S
  1
1
Ki = 6.4 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0449615
 Compound Info 
(S)-1-{2-[4-(4-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-isochroman-6-carboxylic acid amide
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C23H29N3O3
  1
1
Ki = 3023 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0446013
 Compound Info 
(S)-1-(2-(4-(4-methoxyphenyl)piperazin-1-yl)ethyl)-N-methyl-3,4-dihydro-1H-isochromene-6-carboxamide
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C24H31N3O3
  1
1
Ki = 5775 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0402145
 Compound Info 
1-{2-[4-(4-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-isochroman-6-carboxylic acid amide
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C23H29N3O3
  1
1
Ki = 5862 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0391252
 Compound Info 
1-(2-Isochroman-1-yl-ethyl)-4-(4-methoxy-phenyl)-piperazine
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C22H28N2O2
  1
1
Ki = 7242 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0403969
 Compound Info 
(R)-1-{2-[4-(4-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-isochroman-6-carboxylic acid amide
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C23H29N3O3
  1
1
Ki = 26021 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT01202 5-hydroxytryptamine receptor 1B Homo sapiens, Human
 Protein Info