General Information of the Protein
Protein ID
PT06665
Protein Name
Tumor necrosis factor receptor superfamily member 6
Secondarily
Protein Name
Apo-1 antigen
Apoptosis-mediating surface antigen FAS
FASLG receptor
Gene Name
FAS
Secondarily
Gene Name
Apt1
Tnfrsf6
Sequence
MLWIMAVLPLVLAGPELNVRMQGTDSIFEGLELKRSVRETDNNCSEGLYQVGPFCCQPCQPGERKVKDCTTSGGAPTCHPCTEGEEYTDRKHYSDKCRRCAFCDEGHGLEVETNCTRTQNTKCRCKENFYCNASLCDHCYHCTSCGLEDILEPCTRTSNTKCKKQSSNYKLLWLLILPGLAILFVFIYKRYRKRQPGDPESGIPSPESVPMNVSDVNLNKYIWRTAEKMKICDAKKFARQHKIPESKIDEIEHNSPQDAAEQKIQLLQCWYQSHGKTGACQALIQGLRKANRCDIAEEIQAMVWEDHENSISNSRNENEGQSLE
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Organism
Rattus norvegicus, Rat
Protein Classification
Membrane receptor
Function
Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both (By similarity).
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Uniprot ID
Q63199
Ensembl ID
ENSG00000026103
Subcellular Location
Cell membrane
Membrane raft
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000378 , H9c2(2-1)
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0408518
 Compound Info 
methyl 4-[[2-(4-bromophenoxy)acetyl]amino]-1-(2-phenylethyl)pyrazole-3-carboxylate
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C21H20BrN3O4
  1
1
EC50 = 354.81 nM
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CP0411596
 Compound Info 
methyl 3-[[2-(4-bromophenyl)sulfanylacetyl]amino]thiophene-2-carboxylate
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C14H12BrNO3S2
  1
1
EC50 = 426.58 nM
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CP0449895
 Compound Info 
methyl 1-(2-phenylethyl)-4-(3-phenylpropanoylamino)pyrazole-3-carboxylate
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C22H23N3O3
  1
1
EC50 = 426.58 nM
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CP0408519
 Compound Info 
methyl 4-[[2-(3-methoxyphenyl)sulfanylacetyl]amino]-2-(2-phenylethyl)pyrazole-3-carboxylate
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C22H23N3O4S
  1
1
EC50 = 436.52 nM
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CP0449894
 Compound Info 
methyl 4-[[2-(4-nitrophenyl)sulfanylacetyl]amino]-2-(2-phenylethyl)pyrazole-3-carboxylate
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C21H20N4O5S
  1
1
EC50 = 457.09 nM
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CP0540330
 Compound Info 
methyl 3-(3-pyridin-2-ylsulfanylpropanoylamino)thieno[2,3-b]pyridine-2-carboxylate
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C17H15N3O3S2
  1
1
EC50 = 489.78 nM
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CP0465917
 Compound Info 
methyl 3-(3-phenylsulfanylpropanoylamino)thiophene-2-carboxylate
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C15H15NO3S2
  1
1
EC50 = 501.19 nM
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CP0510422
 Compound Info 
methyl 4-[[2-(4-bromophenyl)sulfanylacetyl]amino]-2-(2-phenylethyl)pyrazole-3-carboxylate
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C21H20BrN3O3S
  1
1
EC50 = 512.86 nM
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CP0538976
 Compound Info 
methyl 4-[[2-(2-aminophenyl)sulfanylacetyl]amino]-2-(2-phenylethyl)pyrazole-3-carboxylate
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C21H22N4O3S
  1
1
EC50 = 512.86 nM
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CP0449893
 Compound Info 
methyl 2-[(2-phenylsulfanylacetyl)amino]benzoate
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C16H15NO3S
  1
1
EC50 = 562.34 nM
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CP0510424
 Compound Info 
methyl 3-[[2-(3-methoxyphenyl)sulfanylacetyl]amino]thiophene-2-carboxylate
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C15H15NO4S2
  1
1
EC50 = 575.44 nM
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CP0544510
 Compound Info 
methyl 3-[[2-(4-nitrophenyl)sulfanylacetyl]amino]-1-benzofuran-2-carboxylate
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C18H14N2O6S
  1
1
EC50 = 575.44 nM
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CP0465914
 Compound Info 
methyl 2-[3-(4-bromophenyl)sulfanylpropanoylamino]thiophene-3-carboxylate
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C15H14BrNO3S2
  1
1
EC50 = 588.84 nM
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CP0510425
 Compound Info 
methyl 4-chloro-3-(3-pyridin-2-ylsulfanylpropanoylamino)-1-benzofuran-2-carboxylate
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C18H15ClN2O4S
  1
1
EC50 = 630.96 nM
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CP0449890
 Compound Info 
methyl 4-chloro-3-[(2-pyridin-2-ylsulfanylacetyl)amino]-1-benzofuran-2-carboxylate
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C17H13ClN2O4S
  1
1
EC50 = 645.65 nM
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CP0498743
 Compound Info 
methyl 3-[[2-(4-bromophenyl)sulfanylacetyl]amino]-1-benzofuran-2-carboxylate
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C18H14BrNO4S
  1
1
EC50 = 660.69 nM
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CP0510423
 Compound Info 
methyl 3-[[2-(N-methylanilino)acetyl]amino]thiophene-2-carboxylate
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C15H16N2O3S
  1
1
EC50 = 660.69 nM
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CP0296669
 Compound Info 
2-[[1-oxo-2-(2-pyridinylthio)ethyl]amino]benzoic acid methyl ester
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C15H14N2O3S
  1
1
EC50 = 691.83 nM
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CP0465916
 Compound Info 
methyl 3-[(2-phenylsulfanylacetyl)amino]-1-benzothiophene-2-carboxylate
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C18H15NO3S2
  1
1
EC50 = 691.83 nM
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CP0408481
 Compound Info 
methyl 2-[(2-phenylsulfanylacetyl)amino]thiophene-3-carboxylate
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C14H13NO3S2
  1
1
EC50 = 724.44 nM
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CP0473680
 Compound Info 
3-[[2-(4-bromophenyl)sulfanylacetyl]amino]-1-benzofuran-2-carboxylic acid
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C17H12BrNO4S
  1
1
EC50 = 724.44 nM
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CP0538977
 Compound Info 
methyl 3-[3-(4-bromophenyl)sulfanylpropanoylamino]-1-benzothiophene-2-carboxylate
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C19H16BrNO3S2
  1
1
EC50 = 724.44 nM
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CP0540328
 Compound Info 
methyl 2-[[2-(4-bromophenyl)sulfanylacetyl]amino]thiophene-3-carboxylate
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C14H12BrNO3S2
  1
1
EC50 = 758.58 nM
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CP0540588
 Compound Info 
methyl 3-[(2-phenylsulfanylacetyl)amino]thiophene-2-carboxylate
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C14H13NO3S2
  1
1
EC50 = 794.33 nM
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CP0498744
 Compound Info 
3-[[2-(4-bromophenyl)sulfanylacetyl]amino]-N,N-dimethylthiophene-2-carboxamide
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C15H15BrN2O2S2
  1
1
EC50 = 851.14 nM
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CP0538975
 Compound Info 
methyl 3-[[2-(4-methoxyphenyl)sulfanylacetyl]amino]thiophene-2-carboxylate
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C15H15NO4S2
  1
1
EC50 = 870.96 nM
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CP0458317
 Compound Info 
methyl 3-[[2-(4-bromophenoxy)acetyl]amino]thiophene-2-carboxylate
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C14H12BrNO4S
  1
1
EC50 = 891.25 nM
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CP0540332
 Compound Info 
methyl 3,5-dibromo-2-(3-pyridin-2-ylsulfanylpropanoylamino)benzoate
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C16H14Br2N2O3S
  1
1
EC50 = 933.25 nM
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CP0465913
 Compound Info 
methyl 2-[[2-(4-bromophenyl)sulfanylacetyl]amino]-4-chlorobenzoate
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C16H13BrClNO3S
  1
1
EC50 = 954.99 nM
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CP0540329
 Compound Info 
2-(4-bromophenyl)sulfanyl-N-[2-(4,5-dihydro-1,3-oxazol-2-yl)-4,5-dimethoxyphenyl]acetamide
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C19H19BrN2O4S
  1
1
EC50 = 954.99 nM
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CP0540586
 Compound Info 
methyl 4-chloro-2-(3-pyridin-2-ylsulfanylpropanoylamino)benzoate
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C16H15ClN2O3S
  1
1
EC50 = 1023.29 nM
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CP0465918
 Compound Info 
methyl 3-[[2-(4-bromophenoxy)acetyl]amino]-1-benzofuran-2-carboxylate
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C18H14BrNO5
  1
1
EC50 = 1047.13 nM
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CP0544492
 Compound Info 
methyl 3,4,5-trimethoxy-2-(3-pyridin-2-ylsulfanylpropanoylamino)benzoate
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C19H22N2O6S
  1
1
EC50 = 1071.52 nM
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CP0498742
 Compound Info 
3-[[2-(4-bromophenyl)sulfanylacetyl]amino]-4-methylthiophene-2-carboxylic acid
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C14H12BrNO3S2
  1
1
EC50 = 1122.02 nM
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CP0408517
 Compound Info 
methyl 3-[[2-(4-bromophenyl)sulfanylacetyl]amino]-4-chloro-1-benzofuran-2-carboxylate
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C18H13BrClNO4S
  1
1
EC50 = 1148.15 nM
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CP0449891
 Compound Info 
1-[(2R)-6-amino-2-(dimethoxymethyl)-2,3-dimethyl-3,4-dihydrochromen-4-yl]-2-benzyl-3-cyanoguanidine
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C23H29N5O3
  1
1
EC50 = 1202.26 nM
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CP0510426
 Compound Info 
3,5-dibromo-2-[[2-(4-bromophenyl)sulfanylacetyl]amino]benzoic acid
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C15H10Br3NO3S
  1
1
EC50 = 1230.27 nM
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CP0449892
 Compound Info 
methyl 3-[3-(4-bromophenyl)sulfanylpropanoylamino]thiophene-2-carboxylate
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C15H14BrNO3S2
  1
1
EC50 = 1288.25 nM
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CP0487828
 Compound Info 
methyl 4,5-dimethoxy-2-(3-pyridin-2-ylsulfanylpropanoylamino)benzoate
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C18H20N2O5S
  1
1
EC50 = 1318.26 nM
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CP0540589
 Compound Info 
methyl 3,5-dibromo-2-[[2-(4-bromophenyl)sulfanyl-2-phenylacetyl]amino]benzoate
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C22H16Br3NO3S
  1
1
EC50 = 1584.89 nM
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CP0465915
 Compound Info 
N-[5-chloro-2-(4,5-dihydro-1,3-oxazol-2-yl)phenyl]-3-pyridin-2-ylsulfanylpropanamide
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C17H16ClN3O2S
  1
1
EC50 = 1737.8 nM
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CP0449889
 Compound Info 
2-[[2-(4-bromophenyl)sulfanyl-2-phenylacetyl]amino]-5-chlorobenzoic acid
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C21H15BrClNO3S
  1
1
EC50 = 1995.26 nM
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CP0458318
 Compound Info 
3,4,5-trimethoxy-2-(3-pyridin-2-ylsulfanylpropanoylamino)benzoic acid
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C18H20N2O6S
  1
1
EC50 = 2089.3 nM
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CP0465912
 Compound Info 
2-[[2-(4-bromophenyl)sulfanylacetyl]amino]benzoic acid
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C15H12BrNO3S
  1
1
EC50 = 2238.72 nM
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