General Information of the Protein
Protein ID
PT06647
Protein Name
Solute carrier family 12 member 5
Secondarily
Protein Name
Electroneutral potassium-chloride cotransporter 2
K-Cl cotransporter 2
Neuronal K-Cl cotransporter
Gene Name
SLC12A5
Secondarily
Gene Name
KCC2
KIAA1176
Sequence
MSRRFTVTSLPPAGPARSPDPESRRHSVADPRHLPGEDVKGDGNPKESSPFINSTDTEKGKEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSREHEEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRLWGLFCSSRFLNATCDEYFTRNNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERSGMTSVGLADGTPIDMDHPYVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRETTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRIFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILKQMHLTKNEREREIQSITDESRGSIRRKNPANTRLRLNVPEETAGDSEEKPEEEVQLIHDQSAPSCPSSSPSPGEEPEGEGETDPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSMKPEWENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEHLDRVMLVRGGGREVITIYS
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Organism
Homo sapiens, Human
Protein Classification
Transporter
>
Electrochemical transporter
>
SLC superfamily of solute carriers
>
SLC12 family of cation-coupled chloride transporters
Function
Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis (PubMed:12106695). As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition (By similarity). Involved in the regulation of dendritic spine formation and maturation (PubMed:24668262).
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Uniprot ID
Primary ID:
Q9H2X9

Secondarily ID:
A2RTX2
Q5VZ41
Q9H4Z0
Q9ULP4
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Ensembl ID
ENSG00000124140
HGNC ID
HGNC:13818
Subcellular Location
Cell membrane
Cell projection
Dendrite
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0405825
 Compound Info 
N-cyclopropyl-N-(4-methyl-1,3-thiazol-2-yl)-2-(6-phenylpyridazin-3-yl)sulfanylacetamide
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C19H18N4OS2
  1
1
IC50 = 61 nM
 Bioactivity Info 
   TI
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   LO
   TS
CP0524669
 Compound Info 
N-cyclobutyl-N-(4-methyl-1,3-thiazol-2-yl)-2-(6-phenylpyridazin-3-yl)sulfanylacetamide
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C20H20N4OS2
  1
1
IC50 = 177 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0405823
 Compound Info 
N-methyl-N-(4-methyl-1,3-thiazol-2-yl)-2-(6-phenylpyridazin-3-yl)sulfanylacetamide
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C17H16N4OS2
  1
1
IC50 = 537 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0006534
 Compound Info 
N-(4-methyl-1,3-thiazol-2-yl)-2-(6-phenylpyridazin-3-yl)sulfanyl-ethanamide
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C16H14N4OS2
  1
1
IC50 = 568 nM
 Bioactivity Info 
   TI
   LI
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   TS
CP0405829
 Compound Info 
6-amino-5-[2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetyl]-3-methyl-1-propyl-1,3-diazinane-2,4-dione
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C19H23N5O4S
  1
1
IC50 = 640 nM
 Bioactivity Info 
   TI
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   TS
CP0405828
 Compound Info 
N-cyclopentyl-N-(4-methyl-1,3-thiazol-2-yl)-2-(6-phenylpyridazin-3-yl)sulfanylacetamide
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C21H22N4OS2
  1
1
IC50 = 1057 nM
 Bioactivity Info 
   TI
   LI
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   TS
CP0011780
 Compound Info 
3-benzyl-6-[2-(4-chlorophenyl)-2-keto-ethyl]triazolo[4,5-d]pyrimidin-7-one
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C19H14ClN5O2
  1
1
IC50 = 1200 nM
 Bioactivity Info 
   TI
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CP0494039
 Compound Info 
N-methyl-N-(4-methyl-1,3-thiazol-2-yl)-2-(5-phenylpyridin-2-yl)sulfanylacetamide
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C18H17N3OS2
  1
1
IC50 = 2900 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0416711
 Compound Info 
N-(4-methyl-1,3-thiazol-2-yl)-2-(5-phenylpyridin-2-yl)sulfanylacetamide
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C17H15N3OS2
  1
1
IC50 = 6900 nM
 Bioactivity Info 
   TI
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Clinical Information about the Protein
Target 1 ( Solute carrier family 12 member 5 (SLC12A5) )
Target Type Literature-reported Target