General Information of the Protein
Protein ID
PT06646
Protein Name
Uracil nucleotide/cysteinyl leukotriene receptor
Secondarily
Protein Name
G-protein coupled receptor 17
Gene Name
GPR17
Sequence
MNGLEAALPSLTDNSSLAYSEQCGQETPLENMLFACFYLLDFILAFVGNALALWLFIWDHKSGTPANVFLMHLAVADLSCVLVLPTRLVYHFSGNHWPFGEIPCRLTGFLFYLNMYASIYFLTCISADRFLAIVHPVKSLKLRRPLYAHLACAFLWIVVAVAMAPLLVSPQTVQTNHTVVCLQLYREKASHHALASLAVAFTFPFITTVTCYLLIIRSLRQGPRIEKHLKNKAVRMIAMVLAIFLICFVPYHIHRSVYVLHYRGGGTSCAAQRALALGNRITSCLTSLNGALDPVMYFFVAEKFRHALCNLLCSKRLTGPPPSFEGKTNESSLSARSEL
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Organism
Mus musculus, Mouse
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
Function
Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia (By similarity).
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Uniprot ID
Primary ID:
Q6NS65

Secondarily ID:
Q80UD2
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Ensembl ID
ENSG00000144230
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0196179
 Compound Info 
3-(2-Carboxy-ethyl)-4,6-dichloro-1H-indole-2-carboxylic acid
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C12H9Cl2NO4
  1
1
EC50 = 1110 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0405488
 Compound Info 
3-(2-carboxyethyl)-4-chloro-6-hexoxy-1H-indole-2-carboxylic acid
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C18H22ClNO5
  1
1
EC50 = 3030 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT06522 Uracil nucleotide/cysteinyl leukotriene receptor Rattus norvegicus, Rat
 Protein Info 
50% Identity
Protein ID Protein Name Protein Organism
PT05061 Uracil nucleotide/cysteinyl leukotriene receptor Homo sapiens, Human
 Protein Info