General Information of the Protein
Protein ID
PT06637
Protein Name
Low-density lipoprotein receptor-related protein 6
Gene Name
LRP6
Sequence
MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTLLGDYVYWTDWQRRSIERVHKRSAEREVIIDQLPDLMGLKATNVHRVIGSNPCAEENGGCSHLCLYRPQGLRCACPIGFELISDMKTCIVPEAFLLFSRRADIRRISLETNNNNVAIPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLVPNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVIADDLPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQSGWNECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCSAPTTFLLFSQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCPVCSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDCYPTEEPAPQATNTVGSVIGVIVTIFVSGTVYFICQRMLCPRMKGDGETMTNDYVVHGPASVPLGYVPHPSSLSGSLPGMSRGKSMISSLSIMGGSSGPPYDRAHVTGASSSSSSSTKGTYFPAILNPPPSPATERSHYTMEFGYSSNSPSTHRSYSYRPYSYRHFAPPTTPCSTDVCDSDYAPSRRMTSVATAKGYTSDLNYDSEPVPPPPTPRSQYLSAEENYESCPPSPYTERSYSHHLYPPPPSPCTDSS
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Organism
Homo sapiens, Human
Protein Classification
Unclassified protein
Function
Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalosomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity).
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Uniprot ID
Primary ID:
O75581

Secondarily ID:
Q17RZ2
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Ensembl ID
ENSG00000070018
HGNC ID
HGNC:6698
Subcellular Location
Cell membrane
Endoplasmic reticulum
Membrane raft
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0455101
 Compound Info 
7-(dimethylamino)-4-hydroxy-3-oxophenoxazin-10-ium-1-carboxylic acid;chloride
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C15H13ClN2O5
  2
1
IC50 = 3000 nM
 Bioactivity Info 
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2
IC50 = 6380 nM
 Bioactivity Info 
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CP0404363
 Compound Info 
butyl 7-(dimethylamino)-2-[(4-methoxyphenyl)methylamino]-3,4-dioxo-10H-phenoxazine-1-carboxylate
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C27H29N3O6
  1
1
IC50 = 3380 nM
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CP0458923
 Compound Info 
methyl 7-(dimethylamino)-2-morpholin-4-yl-3,4-dioxo-10H-phenoxazine-1-carboxylate
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C20H21N3O6
  1
1
IC50 = 3740 nM
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CP0474398
 Compound Info 
methyl 7-(dimethylamino)-2-(4-methylanilino)-3,4-dioxo-10H-phenoxazine-1-carboxylate
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C23H21N3O5
  1
1
IC50 = 3770 nM
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CP0408024
 Compound Info 
CHEMBL3764205
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C22H25N3O5
  1
1
IC50 = 4060 nM
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CP0407927
 Compound Info 
CHEMBL3765415
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C24H23N3O6
  1
1
IC50 = 4330 nM
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CP0408025
 Compound Info 
methyl 2-(cyclopentylamino)-7-(dimethylamino)-3,4-dioxo-10H-phenoxazine-1-carboxylate
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C21H23N3O5
  1
1
IC50 = 4610 nM
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CP0487888
 Compound Info 
methyl 7-(dimethylamino)-2-(4-methoxyanilino)-3,4-dioxo-10H-phenoxazine-1-carboxylate
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C23H21N3O6
  1
1
IC50 = 4710 nM
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CP0452498
 Compound Info 
methyl 2-(3,4-dichloroanilino)-7-(dimethylamino)-3,4-dioxo-10H-phenoxazine-1-carboxylate
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C22H17Cl2N3O5
  1
1
IC50 = 4870 nM
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CP0407926
 Compound Info 
methyl 2-amino-7-(dimethylamino)-3,4-dioxo-10H-phenoxazine-1-carboxylate
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C16H15N3O5
  1
1
IC50 = 5230 nM
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CP0434831
 Compound Info 
methyl 7-(dimethylamino)-3,4-dioxo-2-piperidin-1-yl-10H-phenoxazine-1-carboxylate
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C21H23N3O5
  1
1
IC50 = 5500 nM
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CP0447133
 Compound Info 
methyl 2-anilino-7-(dimethylamino)-3,4-dioxo-10H-phenoxazine-1-carboxylate
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C22H19N3O5
  1
1
IC50 = 6160 nM
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Clinical Information about the Protein
Target 1 ( LDL receptor related protein-6 (LRP-6) )
Target Type Clinical trial Target