General Information of the Protein
Protein ID
PT06580
Protein Name
Neuronal acetylcholine receptor subunit alpha-2
Gene Name
CHRNA2
Secondarily
Gene Name
Acra2
Sequence
MTLSHSALQFWTHLYLWCLLLVPAVLTQQGSHTHAEDRLFKHLFGGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWNDYKLRWDPAEFGNVTSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFFTGTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMERTVDLKDYWESGEWAIINATGTYNSKKYDCCAEIYPDVTYYFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHNMPNWVRVALLGRVPRWLMMNRPLPPMELHGSPDLKLSPSYHWLETNMDAGEREETEEEEEEEDENICVCAGLPDSSMGVLYGHGGLHLRAMEPETKTPSQASEILLSPQIQKALEGVHYIADRLRSEDADSSVKEDWKYVAMVVDRIFLWLFIIVCFLGTIGLFLPPFLAGMI
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Organism
Rattus norvegicus, Rat
Protein Classification
Ion channel
>
Ligand-gated ion channel
>
Nicotinic acetylcholine receptor
>
Nicotinic acetylcholine receptor alpha subunit
Function
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
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Uniprot ID
Primary ID:
P12389

Secondarily ID:
O08952
Q53YK3
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Subcellular Location
Postsynaptic cell membrane
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0004884
 Compound Info 
(+)-7-Methyl-2-exo-[3'-(2-fluoropyridin-4-yl)-5'-pyridinyl]-7-azabicyclo[2.2.1]heptane
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C17H18FN3
  1
1
Ki = 0.015 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0002250
 Compound Info 
2-Chloro-3-(2-fluoro-4-(pyridinyl)methoxy)-5-((1-methyl-2-(S)-pyrrolidinyl)methoxy)pyridine
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C17H19ClFN3O2
  1
1
Ki = 0.022 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0000212
 Compound Info 
()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]heptane
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C11H13ClN2
  1
1
Ki = 0.025 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0008009
 Compound Info 
2-Chloro-3-(2-chloro-5-(pyridinyl)methoxy)-5-((1-methyl)-2-(S)-pyrrolidinyl)methoxy)pyridine
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C17H19Cl2N3O2
  1
1
Ki = 0.031 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0001488
 Compound Info 
(+)-7-Methyl-2-exo-[3'-(2-fluoropyridin-3-yl)-5'-pyridinyl]-7-azabicyclo[2.2.1]heptane
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C17H18FN3
  1
1
Ki = 0.034 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0007625
 Compound Info 
2-Chloro-3-(2-fluoro-4-(pyridinyl)methoxy)-5-(2-(S)-pyrrolidinyl)methoxy)-pyridine
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C16H17ClFN3O2
  1
1
Ki = 0.035 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0002251
 Compound Info 
(S)-2-chloro-2'-fluoro-5-((1-methylpyrrolidin-2-yl)methoxy)-3,4'-bipyridine
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C16H17ClFN3O
  1
1
Ki = 0.05 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0001489
 Compound Info 
(+)-7-Methyl-2-exo-[3'-(6-fluoropyridin-2-yl)-5'-pyridinyl]-7-azabicyclo[2.2.1]heptane
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C17H18FN3
  1
1
Ki = 0.26 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0003732
 Compound Info 
(S)-3-(azetidin-2-ylmethoxy)-2-fluoropyridine
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C9H11FN2O
  1
1
Ki = 1.4 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0634014
 Compound Info 
(S)-3-(azetidin-2-ylmethoxy)-2-[18F]fluoropyridine
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C9H11FN2O
  1
1
Ki = 1.44 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0007619
 Compound Info 
2-Chloro-3-(2-chloro-5-(pyridinyl)methoxy)-5-((1-methyl)-2-(R)-pyrrolidinyl)methoxy)pyridine
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C17H19Cl2N3O2
  1
1
Ki = 1.5 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0000063
 Compound Info 
CAS_29790-52-1
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C10H14N2
  1
1
Ki = 12 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT02515 Neuronal acetylcholine receptor subunit alpha-3 Homo sapiens, Human
 Protein Info