General Information of the Protein
Protein ID
PT06563
Protein Name
Sodium-dependent phosphate transport protein 2C
Secondarily
Protein Name
Na(+)-dependent phosphate cotransporter 2C
Sodium/inorganic phosphate cotransporter IIC
Sodium/phosphate cotransporter 2C
Solute carrier family 34 member 3
Gene Name
SLC34A3
Secondarily
Gene Name
NPT2C
NPTIIC
Sequence
MPSSLPGSQVPHPTLDAVDLVEKTLRNEGTSSSAPVLEEGDTDPWTLPQLKDTSQPWKELRVAGRLRRVAGSVLKACGLLGSLYFFICSLDVLSSAFQLLGSKVAGDIFKDNVVLSNPVAGLVIGVLVTALVQSSSTSSSIVVSMVAAKLLTVRVSVPIIMGVNVGTSITSTLVSMAQSGDRDEFQRAFSGSAVHGIFNWLTVLVLLPLESATALLERLSELALGAASLTPRAQAPDILKVLTKPLTHLIVQLDSDMIMSSATGNATNSSLIKHWCGTTGQPTQENSSCGAFGPCTEKNSTAPADRLPCRHLFAGTELTDLAVGCILLAGSLLVLCGCLVLIVKLLNSVLRGRVAQVVRTVINADFPFPLGWLGGYLAVLAGAGLTFALQSSSVFTAAVVPLMGVGVISLDRAYPLLLGSNIGTTTTALLAALASPADRMLSALQVALIHFFFNLAGILLWYLVPALRLPIPLARHFGVVTARYRWVAGVYLLLGFLLLPLAAFGLSLAGGMELAAVGGPLVGLVLLVILVTVLQRRRPAWLPVRLRSWAWLPVWLHSLEPWDRLVTRCCPCNVCSPPKATTKEAYCYENPEILASQQL
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Organism
Homo sapiens, Human
Protein Classification
Transporter
>
Electrochemical transporter
>
SLC superfamily of solute carriers
>
SLC34 family of sodium phosphate co-transporters
Function
Involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane (PubMed:11880379). The cotransport has a Na(+):Pi stoichiometry of 2:1 and is electroneutral (By similarity).
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Uniprot ID
Primary ID:
Q8N130

Secondarily ID:
A2BFA1
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Ensembl ID
ENSG00000198569
HGNC ID
HGNC:20305
Subcellular Location
Apical cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
Compound ID Compound Name Compound Formula
CP0875942
N-(4-chloro-2-(2-(3-fluorobenzylidene)hydrazinecarbonyl)phenyl)-3-((2,3-dihydroxypropylthio)methyl)benzamide
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C25H23ClFN3O4S
 1
1
IC50 = 1900 nM
   TI
   LI
   LO
   TS
CP0412050
2-methyl-7-[4-(pyridin-2-ylamino)piperidin-1-yl]-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile
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C20H19F3N6
 1
1
IC50 = 21000 nM
   TI
   LI
   LO
   TS
CP0392939
2-methyl-7-(1-oxo-2,8-diazaspiro[4.5]decan-8-yl)-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile
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C18H18F3N5O
 1
1
IC50 > 25000 nM
   TI
   LI
   LO
   TS
CP0396537
4-amino-1-[3-chloro-6-cyano-2-methyl-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridin-7-yl]piperidine-4-carboxamide
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C16H16ClF3N6O
 1
1
IC50 > 25000 nM
   TI
   LI
   LO
   TS
CP0411999
7-(4-aminopiperidin-1-yl)-3-chloro-2-methyl-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile
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C15H15ClF3N5
 1
1
IC50 > 25000 nM
   TI
   LI
   LO
   TS
CP0412052
3-chloro-2-methyl-7-(1-oxo-2,8-diazaspiro[4.5]decan-8-yl)-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile
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C18H17ClF3N5O
 1
1
IC50 > 25000 nM
   TI
   LI
   LO
   TS
CP0432155
3-chloro-7-[(2S)-2-(hydroxymethyl)morpholin-4-yl]-2-methyl-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile
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C15H14ClF3N4O2
 1
1
IC50 > 25000 nM
   TI
   LI
   LO
   TS
CP0538749
3-chloro-7-[(2R)-2-(hydroxymethyl)morpholin-4-yl]-2-methyl-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile
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C15H14ClF3N4O2
 1
1
IC50 > 25000 nM
   TI
   LI
   LO
   TS
CP0852936
3-chloro-7-(4-hydroxypiperidin-1-yl)-2-methyl-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile
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C15H14ClF3N4O
 1
1
IC50 > 25000 nM
   TI
   LI
   LO
   TS
CP0865069
7-(1-oxo-2,8-diazaspiro[4.5]decan-8-yl)-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile
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C17H16F3N5O
 1
1
IC50 > 25000 nM
   TI
   LI
   LO
   TS
CP0852935
3-chloro-2-methyl-7-(2-methyl-1-oxo-2,8-diazaspiro[4.5]decan-8-yl)-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile
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C19H19ClF3N5O
 1
1
IC50 > 60000 nM
   TI
   LI
   LO
   TS
CP0396536
N-(4-chlorophenyl)-5-methoxy-2-[[3-(trifluoromethyl)phenyl]sulfonylamino]benzamide
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C21H16ClF3N2O4S
 1
1
IC50 > 7500 nM
   TI
   LI
   LO
   TS