General Information of the Protein
Protein ID
PT06562
Protein Name
Endothelial lipase
Secondarily
Protein Name
Endothelial cell-derived lipase
Phospholipase A1
Gene Name
LIPG
Sequence
MRNTVFLLGFWSVYCYFPAGSITTLRPQGSLRDEHHKPTGVPATARPSVAFNIRTSKDPEQEGCNLSLGDSKLLENCGFNMTAKTFFIIHGWTMSGMFESWLHKLVSALQMREKDANVVVVDWLPLAHQLYTDAVNNTRVVGQRVAGMLDWLQEKEEFSLGNVHLIGYSLGAHVAGYAGNFVKGTVGRITGLDPAGPMFEGVDINRRLSPDDADFVDVLHTYTLSFGLSIGIRMPVGHIDIYPNGGDFQPGCGFNDVIGSFAYGTISEMVKCEHERAVHLFVDSLVNQDKPSFAFQCTDSSRFKRGICLSCRKNRCNNIGYNAKKMRKKRNSKMYLKTRAGMPFKVYHYQLKVHMFSYNNSGDTQPTLYITLYGSNADSQNLPLEIVEKIELNATNTFLVYTEEDLGDLLKMRLTWEGVAHSWYNLWNEFRNYLSQPSNPSRELYIRRIRVKSGETQRKVTFCTQDPTKSSISPGQELWFHKCQDGWKMKNKTSPFVNLA
    Show/Hide
Organism
Mus musculus, Mouse
Protein Classification
Enzyme
>
Hydrolase
Function
Exerts both phospholipase and triglyceride lipase activities (By similarity). More active as a phospholipase than a triglyceride lipase (By similarity). Hydrolyzes triglycerides, both with short-chain fatty acyl groups (tributyrin) and long-chain fatty acyl groups (triolein) with similar levels of activity toward both types of substrates (By similarity). Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins (By similarity).
    Show/Hide
Uniprot ID
Primary ID:
Q9WVG5

Secondarily ID:
Q8VDU2
    Show/Hide
Ensembl ID
ENSG00000101670
Subcellular Location
Secreted
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000131 , HEK293-F
Compound ID Compound Name Compound Formula
CP0061225
2-benzylsulfonyl-N-[2-(cyclopropylamino)-2-oxoethyl]-2-[6-(6-fluoropyridin-3-yl)-1,3-benzothiazol-2-yl]acetamide
   Show/Hide
C26H23FN4O4S2
 1
1
IC50 = 94 nM
   TI
   LI
   LO
   TS
CP0405325
N-[4-(3,4-dichlorophenyl)butan-2-yl]-1-ethyl-4-hydroxy-5-oxo-2H-pyrrole-3-carboxamide
   Show/Hide
C17H20Cl2N2O3
 1
1
IC50 = 100 nM
   TI
   LI
   LO
   TS
CP0323368
2-methylsulfonyl-2-(6-phenyl-1,3-benzothiazol-2-yl)-N-(2-sulfamoylethyl)acetamide
   Show/Hide
C18H19N3O5S3
 1
1
IC50 = 100 nM
   TI
   LI
   LO
   TS
CP0126236
N-[2-(cyclopropylamino)-2-oxoethyl]-2-[6-(6-fluoropyridin-3-yl)-1,3-benzothiazol-2-yl]-2-(2-methoxyethylsulfonyl)acetamide
   Show/Hide
C22H23FN4O5S2
 1
1
IC50 = 120 nM
   TI
   LI
   LO
   TS
CP0066473
US8987314, B34
   Show/Hide
C21H28N6O6S3
 1
1
IC50 = 190 nM
   TI
   LI
   LO
   TS
CP0127616
US8987314, B3
   Show/Hide
C17H17FN4O5S3
 1
1
IC50 = 200 nM
   TI
   LI
   LO
   TS
CP0259244
N-[(cyclopropyl- carbamoyl) methyl]-2-[6-(6- fluoropyridin-3- yl)-1,3- benzothiazol- 2-yl]-2- methanesulfonyl- acetamide
   Show/Hide
C20H19FN4O4S2
 1
1
IC50 = 290 nM
   TI
   LI
   LO
   TS
CP0120856
US8987314, B101
   Show/Hide
C23H26N4O7S3
 1
1
IC50 = 320 nM
   TI
   LI
   LO
   TS
CP0126235
N-[(cyclopropyl- carbamoyl) methyl]-2-[6-(6- fluoropyridin-3- yl)-1,3- benzothiazol- 2-yl]-2-(3,3,3- trifluoropropane- sulfonyl)acetamide
   Show/Hide
C22H20F4N4O4S2
 1
1
IC50 = 600 nM
   TI
   LI
   LO
   TS