General Information of the Protein
Protein ID
PT06542
Protein Name
Methyl-CpG-binding protein 2
Gene Name
MECP2
Sequence
MVAGMLGLREEKSEDQDLQGLKDKPLKFKKVKKDKKEEKEGKHEPVQPSAHHSAEPAEAGKAETSEGSGSAPAVPEASASPKQRRSIIRDRGPMYDDPTLPEGWTRKLKQRKSGRSAGKYDVYLINPQGKAFRSKVELIAYFEKVGDTSLDPNDFDFTVTGRGSPSRREQKPPKKPKSPKAPGTGRGRGRPKGSGTTRPKAATSEGVQVKRVLEKSPGKLLVKMPFQTSPGGKAEGGGATTSTQVMVIKRPGRKRKAEADPQAIPKKRGRKPGSVVAAAAAEAKKKAVKESSIRSVQETVLPIKKRKTRETVSIEVKEVVKPLLVSTLGEKSGKGLKTCKSPGRKSKESSPKGRSSSASSPPKKEHHHHHHHSESPKAPVPLLPPLPPPPPEPESSEDPTSPPEPQDLSSSVCKEEKMPRGGSLESDGCPKEPAKTQPAVATAATAAEKYKHRGEGERKDIVSSSMPRPNREEPVDSRTPVTERVS
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Organism
Homo sapiens, Human
Protein Classification
Epigenetic regulator
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Methyl-CpG-binding domain
Function
Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).
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Uniprot ID
Primary ID:
P51608

Secondarily ID:
O15233
Q6QHH9
Q7Z384
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Ensembl ID
ENSG00000169057
HGNC ID
HGNC:6990
Subcellular Location
Nucleus
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000013 , Sf9
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0415767
 Compound Info 
US9034574, XXII
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C18H14N2OS
  1
1
IC50 = 610 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0113853
 Compound Info 
BDBM77674
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C17H15N3O2
  1
1
IC50 = 2810 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0566883
 Compound Info 
US9034574, XXIII
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C14H11N3O
  1
1
IC50 = 8590 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0383396
 Compound Info 
N,4-dipyridin-2-yl-1,3-thiazol-2-amine
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C13H10N4S
  1
1
IC50 = 10460 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0395049
 Compound Info 
US9034574, XVII
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C14H12N2OS
  1
1
IC50 = 16900 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0521110
 Compound Info 
US9034574, XXI
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C14H11ClN2S
  1
1
IC50 = 33900 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Clinical Information about the Protein
Target 1 ( Methyl cpg binding protein 2 (MECP2) )
Target Type Clinical trial Target