General Information of the Protein
Protein ID
PT06505
Protein Name
P2Y purinoceptor 1
Secondarily
Protein Name
ATP receptor
Purinergic receptor
Gene Name
P2RY1
Sequence
MTEVPWSAVPNGTDAAFLAGLGSLWGNSTIASTAAVSSSFRCALIKTGFQFYYLPAVYILVFIIGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDVMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLKSLGRLKKKNAIYVSVLVWLIVVVAISPILFYSGTGIRKNKTVTCYDSTSDEYLRSYFIYSMCTTVAMFCIPLVLILGCYGLIVRALIYKDLDNSPLRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLDFQTPEMCDFNDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRKASRRSEANLQSKSEEMTLNILSEFKQNGDTSL
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Organism
Rattus norvegicus, Rat
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Nucleotide-like receptor (family A GPCR)
>
Purine receptor
Function
Receptor for extracellular adenine nucleotides such as ADP (PubMed:7779087). In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and ultimately platelet aggregation (By similarity).
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Uniprot ID
P49651
Ensembl ID
ENSG00000169860
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
Compound ID Compound Name Compound Formula
CP0921730
Phosphono borate-Phosphoric acid di-[5-(6-amino-2-chloro-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl] ester; tri sodium
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C10H14BClN5Na4O12P3
 1
1
EC50 = 1 nM
   TI
   LI
   LO
   TS
CP0103899
2-MeSATP
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C11H18N5O13P3S
 1
1
EC50 = 1 nM
   TI
   LI
   LO
   TS
CP0498484
[[(2R,3S,4R)-5-(6-amino-2-methylsulfanylpurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphinothioyl] phosphono hydrogen phosphate
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C11H18N5O12P3S2
 1
1
EC50 = 1 nM
   TI
   LI
   LO
   TS
CP0880580
Phosphono borate-Phosphoric acid di-[5-(6-amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl] ester; tri sodium
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C10H15BN5Na4O12P3
 1
1
EC50 = 2 nM
   TI
   LI
   LO
   TS
CP0896045
Phosphoric acid tri-[5-(6-amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl] ester; tri sodium
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C10H12N5Na4O13P3
 1
1
EC50 = 2 nM
   TI
   LI
   LO
   TS
CP0854267
Phosphono borate-Phosphoric acid di-[5-(6-amino-2-methyl sulfanyl-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl] ester; tri sodium
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C11H17BN5Na4O12P3S
 1
1
EC50 = 2.6 nM
   TI
   LI
   LO
   TS
CP0880791
alpha-borano-2-MeS-ATP
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C11H17BN5Na4O12P3S
 1
1
EC50 = 2.6 nM
   TI
   LI
   LO
   TS
CP0916422
Phosphoric acid tri-[5-(6-amino-2-chloro-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl] ester; tri sodium
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C10H11ClN5Na4O13P3
 1
1
EC50 = 3.6 nM
   TI
   LI
   LO
   TS
CP0926690
Phosphoric acid tri-[5-(6-amino-2-methyl sufanyl-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl] ester; tri sodium
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C11H14N5Na4O13P3S
 1
1
EC50 = 4.5 nM
   TI
   LI
   LO
   TS
CP0396271
CHEMBL2386493
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C10H16BClN5O12P3
 1
1
EC50 = 4.5 nM
   TI
   LI
   LO
   TS
CP0498504
[[(2R,3S,4R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphinothioyl] phosphono hydrogen phosphate
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C10H16N5O12P3S
 1
1
EC50 = 9.4 nM
   TI
   LI
   LO
   TS
CP0498507
[[(2R,3S,4R)-5-(6-amino-2-methylsulfanylpurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphinothioyl] phosphono hydrogen phosphate
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C11H18N5O12P3S2
 1
1
EC50 = 20 nM
   TI
   LI
   LO
   TS
CP0056956
A(5')p3(5')A
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C20H27N10O16P3
 1
1
EC50 = 60 nM
   TI
   LI
   LO
   TS
CP0875006
Ap5(gamma-B)A
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C80H165BN15O21P5
 1
1
EC50 = 63 nM
   TI
   LI
   LO
   TS
CP0505464
[[(2R,3S,4R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphinothioyl] phosphono hydrogen phosphate
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C10H16N5O12P3S
 1
1
EC50 = 75 nM
   TI
   LI
   LO
   TS
CP0077399
((2R,3S,4R,5R)-5-(6-amino-2-(methylthio)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl trihydrogen diphosphate
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C11H17N5O10P2S
 1
1
EC50 = 100 nM
   TI
   LI
   LO
   TS
CP0029805
({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid
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C10H16N5O13P3
 2
1
EC50 = 200 nM
   TI
   LI
   LO
   TS
2
EC50 = 590 nM
   TI
   LI
   LO
   TS
CP0875002
Ap3(beta-B)A
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C56H109BN13O15P3
 1
1
EC50 = 900 nM
   TI
   LI
   LO
   TS
CP0097473
bis[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl] hydrogen phosphate
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C20H29N10O22P5
 1
1
EC50 >= 5000 nM
   TI
   LI
   LO
   TS
Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT01877 P2Y purinoceptor 1 Homo sapiens, Human