General Information of the Protein
Protein ID
PT06477
Protein Name
Mitogen-activated protein kinase kinase kinase 11
Secondarily
Protein Name
Mixed lineage kinase 3
Gene Name
MAP3K11
Secondarily
Gene Name
Mlk3
Sequence
MEPLKNLFLKSPLGSWNGSGSGGGGGTGGVRPEGSPKATAAYANPVWTALFDYEPNGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIEGDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGAGDSPTFPRFRAIQLEPTESGQTWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSPEPEEPRRAGPTERGNSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGLSRERGESPTAPPPAQMPSPCPPELPSTPLIRLSQTTPDAHSSPTPGPLLLDLGVPSGQPSAKSPRREETRGRTVSPPPGISRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFRGGSQDCRTQTKDMGAQAPWAPEAGP
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Organism
Mus musculus, Mouse
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TKL protein kinase group
>
TKL protein kinase MLK family
>
TKL protein kinase MLK subfamily
Function
Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle (By similarity).
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Uniprot ID
Primary ID:
Q80XI6

Secondarily ID:
Q8K0M8
Q9JJ15
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Ensembl ID
ENSG00000173327
Subcellular Location
Cytoplasm
Cytoskeleton
Microtubule organizing center
Centrosome
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000214 , BV-2
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0206925
 Compound Info 
5-[5-(3,4,5-trimethoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyridin-2-amine
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C21H20N4O3
  1
1
IC50 = 120 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0053431
 Compound Info 
5-[3-(1H-indol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]pyridin-2-amine
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C20H15N5
  1
1
IC50 = 430 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0042910
 Compound Info 
3-(1H-indol-5-yl)-5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridine
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C27H27N5
  1
1
IC50 = 460 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0043046
 Compound Info 
5-[3-(1H-indol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]pyrimidin-2-amine
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C19H14N6
  1
1
IC50 = 510 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0053430
 Compound Info 
5-[5-(3,4,5-trimethoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-2-amine
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C20H19N5O3
  1
1
IC50 = 990 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0718498
 Compound Info 
3-(1H-Indol-5-yl)-5-(3,4,5-trimethoxyphenyl)-1H-pyrrolo-[2,3-b]pyridine
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C24H21N3O3
  1
1
IC50 = 2700 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0075170
 Compound Info 
3-(1H-indol-5-yl)-5-(3,4,5-trimethoxyphenyl)-1H-imidazo[4,5-b]pyrazin-2-one
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C22H19N5O4
  1
1
IC50 = 23600 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT01417 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens, Human
 Protein Info