General Information of the Protein
| Protein ID |
PT06476
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| Protein Name |
Proton-coupled amino acid transporter 1
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| Secondarily Protein Name |
Solute carrier family 36 member 1
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| Gene Name |
SLC36A1
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| Secondarily Gene Name |
PAT1
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| Sequence |
MSTQRLRNEDYHDYSSTDVSPEESPSEGLNNLSSPGSYQRFGQSNSTTWFQTLIHLLKGNIGTGLLGLPLAVKNAGIVMGPISLLIIGIVAVHCMGILVKCAHHFCRRLNKSFVDYGDTVMYGLESSPCSWLRNHAHWGRRVVDFFLIVTQLGFCCVYFVFLADNFKQVIEAANGTTNNCHNNETVILTPTMDSRLYMLSFLPFLVLLVFIRNLRALSIFSLLANITMLVSLVMIYQFIVQRIPDPSHLPLVAPWKTYPLFFGTAIFSFEGIGMVLPLENKMKDPRKFPLILYLGMVIVTILYISLGCLGYLQFGANIQGSITLNLPNCWLYQSVKLLYSIGIFFTYALQFYVPAEIIIPFFVSRAPEHCELVVDLFVRTVLVCLTCILAILIPRLDLVISLVGSVSSSALALIIPPLLEVTTFYSEGMSPLTIFKDALISILGFVGFVVGTYEALYELIQPSNAPIFINSTCAFI
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| Organism |
Homo sapiens, Human
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| Protein Classification |
Transporter
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Electrochemical transporter
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SLC superfamily of solute carriers
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SLC36 family of proton-coupled amino acid transporters
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| Function |
Electrogenic proton/amino acid symporter with selectivity for small apolar L-amino acids, their D-enantiomers and selected amino acid derivatives such as 4-aminobutanoate/GABA (PubMed:12809675, PubMed:12527723, PubMed:19549785). May be involved in the efflux from the lysosomal compartment of neutral amino acids resulting from proteolysis (By similarity). May play a role in specifying sites for exocytosis in neurons (By similarity).
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| Uniprot ID |
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| Ensembl ID | |||||
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| Subcellular Location |
Cell membrane
Apical cell membrane
Lysosome membrane
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Clinical Information about the Protein
Target 1 ( Solute carrier family 36 member 1 (SLC36A1) )
| Target Type | Literature-reported Target | ||||
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