General Information of the Protein
Protein ID
PT06460
Protein Name
Sterol regulatory element-binding protein 2
Secondarily
Protein Name
Class D basic helix-loop-helix protein 2
Sterol regulatory element-binding transcription factor 2
Transcription factor SREBF2
Gene Name
SREBF2
Secondarily
Gene Name
BHLHD2
SREBP2
Sequence
MDDSGELGGLETMETLTELGDELTLGDIDEMLQFVSNQVGEFPDLFSEQLCSSFPGSGGSGSSSGSSGSSSSSSNGRGSSSGAVDPSVQRSFTQVTLPSFSPSAASPQAPTLQVKVSPTSVPTTPRATPILQPRPQPQPQPQTQLQQQTVMITPTFSTTPQTRIIQQPLIYQNAATSFQVLQPQVQSLVTSSQVQPVTIQQQVQTVQAQRVLTQTANGTLQTLAPATVQTVAAPQVQQVPVLVQPQIIKTDSLVLTTLKTDGSPVMAAVQNPALTALTTPIQTAALQVPTLVGSSGTILTTMPVMMGQEKVPIKQVPGGVKQLEPPKEGERRTTHNIIEKRYRSSINDKIIELKDLVMGTDAKMHKSGVLRKAIDYIKYLQQVNHKLRQENMVLKLANQKNKLLKGIDLGSLVDNEVDLKIEDFNQNVLLMSPPASDSGSQAGFSPYSIDSEPGSPLLDDAKVKDEPDSPPVALGMVDRSRILLCVLTFLCLSFNPLTSLLQWGGAHDSDQHPHSGSGRSVLSFESGSGGWFDWMMPTLLLWLVNGVIVLSVFVKLLVHGEPVIRPHSRSSVTFWRHRKQADLDLARGDFAAAAGNLQTCLAVLGRALPTSRLDLACSLSWNVIRYSLQKLRLVRWLLKKVFQCRRATPATEAGFEDEAKTSARDAALAYHRLHQLHITGKLPAGSACSDVHMALCAVNLAECAEEKIPPSTLVEIHLTAAMGLKTRCGGKLGFLASYFLSRAQSLCGPEHSAVPDSLRWLCHPLGQKFFMERSWSVKSAAKESLYCAQRNPADPIAQVHQAFCKNLLERAIESLVKPQAKKKAGDQEEESCEFSSALEYLKLLHSFVDSVGVMSPPLSRSSVLKSALGPDIICRWWTSAITVAISWLQGDDAAVRSHFTKVERIPKALEVTESPLVKAIFHACRAMHASLPGKADGQQSSFCHCERASGHLWSSLNVSGATSDPALNHVVQLLTCDLLLSLRTALWQKQASASQAVGETYHASGAELAGFQRDLGSLRRLAHSFRPAYRKVFLHEATVRLMAGASPTRTHQLLEHSLRRRTTQSTKHGEVDAWPGQRERATAILLACRHLPLSFLSSPGQRAVLLAEAARTLEKVGDRRSCNDCQQMIVKLGGGTAIAAS
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Organism
Homo sapiens, Human
Protein Classification
Transcription factor
Function
Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 2), which is embedded in the endoplasmic reticulum membrane (PubMed:32322062). Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis (PubMed:32322062).
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Uniprot ID
Primary ID:
Q12772

Secondarily ID:
Q05BD5
Q6GTH7
Q86V36
Q9UH04
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Ensembl ID
ENSG00000198911
HGNC ID
HGNC:11290
Subcellular Location
Endoplasmic reticulum membrane
Golgi apparatus membrane
Cytoplasmic vesicle
COPII-coated vesicle membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000026 , CHO-K1
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0004096
 Compound Info 
(1S,2R,5S,10S,11S,14R,15R)-14-[(2R)-6-hydroxy-6-methylheptan-2-yl]-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-7-en-5-ol
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C27H46O2
  1
1
IC50 = 300 nM
 Bioactivity Info 
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CP0389961
 Compound Info 
N-[4-[2-(2-propylpyridin-4-yl)-1,3-thiazol-4-yl]phenyl]methanesulfonamide
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C18H19N3O2S2
  2
1
IC50 = 700 nM
 Bioactivity Info 
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2
IC50 = 1000 nM
 Bioactivity Info 
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CP0494223
 Compound Info 
N-[4-[2-(2-propylpyridin-4-yl)-1,3-thiazol-4-yl]phenyl]thiophene-2-sulfonamide
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C21H19N3O2S3
  1
1
IC50 = 900 nM
 Bioactivity Info 
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CP0511533
 Compound Info 
tert-butyl N-[4-[2-(2-propylpyridin-4-yl)-1,3-thiazol-4-yl]phenyl]carbamate
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C22H25N3O2S
  1
1
IC50 = 1900 nM
 Bioactivity Info 
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CP0503403
 Compound Info 
4-methyl-N-[4-[2-(2-propylpyridin-4-yl)-1,3-thiazol-4-yl]phenyl]benzenesulfonamide
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C24H23N3O2S2
  1
1
IC50 = 2300 nM
 Bioactivity Info 
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CP0503365
 Compound Info 
N-propan-2-yl-4-[2-(2-propylpyridin-4-yl)-1,3-thiazol-4-yl]aniline
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C20H23N3S
  1
1
IC50 = 2800 nM
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CP0431239
 Compound Info 
N-benzyl-4-[2-(2-propylpyridin-4-yl)-1,3-thiazol-4-yl]aniline
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C24H23N3S
  1
1
IC50 = 3000 nM
 Bioactivity Info 
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CP0511529
 Compound Info 
4-(2-methoxyphenyl)-2-(2-propylpyridin-4-yl)-1,3-thiazole
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C18H18N2OS
  1
1
IC50 = 3200 nM
 Bioactivity Info 
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CP0472728
 Compound Info 
N-(cyclopropylmethyl)-4-[2-(2-propylpyridin-4-yl)-1,3-thiazol-4-yl]aniline
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C21H23N3S
  1
1
IC50 = 4900 nM
 Bioactivity Info 
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CP0501691
 Compound Info 
2-(2-propyl-4-pyridyl)-4-(p-tolyl)thiazole;hydrobromide
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C18H18N2S
  2
1
IC50 = 5600 nM
 Bioactivity Info 
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2
IC50 = 10000 nM
 Bioactivity Info 
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CP0511528
 Compound Info 
2-(2-ethylpyridin-4-yl)-4-(4-methylphenyl)-1,3-thiazole
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C17H16N2S
  1
1
IC50 = 6800 nM
 Bioactivity Info 
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CP0532345
 Compound Info 
N-[4-[2-(2-propylpyridin-4-yl)-1,3-thiazol-4-yl]phenyl]acetamide
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C19H19N3OS
  1
1
IC50 = 7100 nM
 Bioactivity Info 
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CP0466546
 Compound Info 
[4-[2-(2-propylpyridin-4-yl)-1,3-thiazol-4-yl]phenyl] benzoate
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C24H20N2O2S
  1
1
IC50 = 7700 nM
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CP0511531
 Compound Info 
4-[2-(2-propylpyridin-4-yl)-1,3-thiazol-4-yl]aniline
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C17H17N3S
  1
1
IC50 = 8600 nM
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CP0431238
 Compound Info 
3-[2-(2-propylpyridin-4-yl)-1,3-thiazol-4-yl]phenol
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C17H16N2OS
  1
1
IC50 = 9500 nM
 Bioactivity Info 
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CP0501658
 Compound Info 
4-[2-(2-propylpyridin-4-yl)-1,3-thiazol-4-yl]phenol
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C17H16N2OS
  1
1
IC50 = 9600 nM
 Bioactivity Info 
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CP0472775
 Compound Info 
4-(4-bromophenyl)-2-(2-propylpyridin-4-yl)-1,3-thiazole
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C17H15BrN2S
  1
1
IC50 = 9800 nM
 Bioactivity Info 
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CP0532344
 Compound Info 
4-(3-methoxyphenyl)-2-(2-propylpyridin-4-yl)-1,3-thiazole
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C18H18N2OS
  1
1
IC50 = 10200 nM
 Bioactivity Info 
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CP0431237
 Compound Info 
4-(4-chlorophenyl)-2-(2-propyl-4-pyridinyl)thiazole;hydrobromide
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C17H15ClN2S
  1
1
IC50 = 10700 nM
 Bioactivity Info 
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CP0494221
 Compound Info 
4-(4-fluorophenyl)-2-(2-propylpyridin-4-yl)-1,3-thiazole
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C17H15FN2S
  1
1
IC50 = 12400 nM
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CP0503401
 Compound Info 
4-(4-methoxyphenyl)-2-(2-propylpyridin-4-yl)-1,3-thiazole
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C18H18N2OS
  1
1
IC50 = 13000 nM
 Bioactivity Info 
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CP0505452
 Compound Info 
2-[2-(2-propylpyridin-4-yl)-1,3-thiazol-4-yl]phenol
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C17H16N2OS
  1
1
IC50 = 14400 nM
 Bioactivity Info 
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CP0452429
 Compound Info 
2-(2-propylpyridin-4-yl)-4-thiophen-2-yl-1,3-thiazole
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C15H14N2S2
  1
1
IC50 = 14700 nM
 Bioactivity Info 
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CP0424924
 Compound Info 
4-(4-methylphenyl)-2-phenyl-1,3-thiazole
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C16H13NS
  1
1
IC50 = 18600 nM
 Bioactivity Info 
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CP0460027
 Compound Info 
4-phenyl-2-(2-propylpyridin-4-yl)-1,3-thiazole
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C17H16N2S
  1
1
IC50 = 23000 nM
 Bioactivity Info 
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CP0242760
 Compound Info 
4-(4-methylphenyl)-2-pyridin-4-yl-1,3-thiazole
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C15H12N2S
  1
1
IC50 > 30000 nM
 Bioactivity Info 
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CP0474890
 Compound Info 
4-[4-(4-methylphenyl)phenyl]-2-propylpyridine
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C21H21N
  1
1
IC50 > 30000 nM
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Clinical Information about the Protein
Target 1 ( SREBP transcription factor 2 (SREBF2) )
Target Type Literature-reported Target