General Information of the Protein
Protein ID
PT06435
Protein Name
Guanine nucleotide-binding protein subunit alpha-11
Secondarily
Protein Name
Guanine nucleotide-binding protein G(y) subunit alpha
Gene Name
GNA11
Secondarily
Gene Name
GA11
Sequence
MTLESMMACCLSDEVKESKRINAEIEKQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGAGYSEEDKRGFTKLVYQNIFTAMQAMIRAMETLKILYKYEQNKANALLIREVDVEKVTTFEHQYVSAIKTLWEDPGIQECYDRRREYQLSDSAKYYLTDVDRIATLGYLPTQQDVLRVRVPTTGIIEYPFDLENIIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLVESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEDKILYSHLVDYFPEFDGPQRDAQAAREFILKMFVDLNPDSDKIIYSHFTCATDTENIRFVFAAVKDTILQLNLKEYNLV
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Organism
Homo sapiens, Human
Protein Classification
Unclassified protein
Function
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:31073061). Acts as an activator of phospholipase C (PubMed:31073061). Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs) (PubMed:27852822). Together with GNAQ, required for heart development (By similarity).
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Uniprot ID
Primary ID:
P29992

Secondarily ID:
O15109
Q14350
Q6IB00
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Ensembl ID
ENSG00000088256
HGNC ID
HGNC:4379
Subcellular Location
Cell membrane
Cytoplasm
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000026 , CHO-K1
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0389384
 Compound Info 
[(1R)-1-[(3S,6S,9S,12R,18R,21S,22R)-21-acetamido-18-benzyl-3-[(1R)-1-methoxyethyl]-4,9,10,12,16,22-hexamethyl-15-methylidene-2,5,8,11,14,17,20-heptaoxo-1,19-dioxa-4,7,10,13,16-pentazacyclodocos-6-yl]-2-methylpropyl] (2S,3R)-2-acetamido-3-hydroxy-4-methylpentanoate
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C46H69N7O15
  1
1
IC50 = 36600 nM
 Bioactivity Info 
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CP0389380
 Compound Info 
[(1R)-1-[(3S,6S,9S,12S,15R,18R,21S,22R)-21-acetamido-15-(hydroxymethyl)-3-[(1R)-1-methoxyethyl]-4,9,10,12,16,22-hexamethyl-18-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,19-dioxa-4,7,10,13,16-pentazacyclodocos-6-yl]-2-methylpropyl] (2S,3R)-2-acetamido-3-hydroxy-4-methylpentanoate
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C43H73N7O16
  1
1
IC50 > 50000 nM
 Bioactivity Info 
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CP0411802
 Compound Info 
[(1R)-1-[(3S,6S,9S,12S,18R,21S,22S)-21-acetamido-18-benzyl-3-[(1R)-1-methoxyethyl]-4,9,10,12,16,22-hexamethyl-15-methylidene-2,5,8,11,14,17,20-heptaoxo-1,19-dioxa-4,7,10,13,16-pentazacyclodocos-6-yl]-2-methylpropyl] (2S,3R)-2-acetamido-3-hydroxy-4-methylpentanoate
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C46H69N7O15
  1
1
IC50 > 50000 nM
 Bioactivity Info 
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Clinical Information about the Protein
Target 1 ( G-alpha-11 messenger RNA (GNA11 mRNA) )
Target Type Literature-reported Target