General Information of the Protein
Protein ID
PT06430
Protein Name
DEP domain-containing mTOR-interacting protein
Secondarily
Protein Name
DEP domain-containing protein 6
Gene Name
DEPTOR
Secondarily
Gene Name
DEPDC6
Sequence
MEEGGSTGSAGSDSSTSGSGGAQQRELERMAEVLVTGEQLRLRLHEEKVIKDRRHHLKTYPNCFVAKELIDWLIEHKEASDRETAIKLMQKLADRGIIHHVCDEHKEFKDVKLFYRFRKDDGTFPLDNEVKAFMRGQRLYEKLMSPENTLLQPREEEGVKYERTFMASEFLDWLVQEGEATTRKEAEQLCHRLMEHGIIQHVSNKHPFVDSNLLYQFRMNFRRRRRLMELLNEKSPSSQETHDSPFCLRKQSHDNRKSTSFMSVSPSKEIKIVSAVRRSSMSSCGSSGYFSSSPTLSSSPPVLCNPKSVLKRPVTSEELLTPGAPYARKTFTIVGDAVGWGFVVRGSKPCHIQAVDPSGPAAAAGMKVCQFVVSVNGLNVLHVDYRTVSNLILTGPRTIVMEVMEELEC
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Organism
Homo sapiens, Human
Protein Classification
Unclassified protein
Function
Negative regulator of the mTORC1 and mTORC2 complexes: inhibits the protein kinase activity of MTOR, thereby inactivating both complexes (PubMed:19446321, PubMed:22017875, PubMed:22017876, PubMed:22017877, PubMed:25936805, PubMed:29382726, PubMed:34519269, PubMed:34519268). DEPTOR inhibits mTORC1 and mTORC2 to induce autophagy (PubMed:22017875, PubMed:22017876, PubMed:22017877). In contrast to AKT1S1/PRAS40, only partially inhibits mTORC1 activity (PubMed:34519269, PubMed:34519268).
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Uniprot ID
Primary ID:
Q8TB45

Secondarily ID:
B2RCL9
B4DN97
E7EV87
Q96EQ1
Q9H0R7
Q9H894
Q9HA07
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Ensembl ID
ENSG00000155792
HGNC ID
HGNC:22953
Subcellular Location
Lysosome membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000186 , RPMI-8226
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0855455
 Compound Info 
N'-(Perchlorocyclopenta-2,4-dien-1-yli-dene)benzohydrazide
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C12H6Cl4N2O
  1
1
IC50 = 600 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0883965
 Compound Info 
1-(3-Fluorophenyl)-2-(perchlorocyclopenta-2,4-dien-1-ylidene)hydrazine
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C11H5Cl4FN2
  1
1
IC50 = 600 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0904881
 Compound Info 
1-(Perchlorocyclopenta-2,4-dien-1-ylidene)-2-phenylhydrazine
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C11H6Cl4N2
  1
1
IC50 = 700 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0867599
 Compound Info 
N-Benzoyl-N'-(perchlorocyclopenta-2,4-dien-1-ylidene)benzohydrazide
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C19H10Cl4N2O2
  1
1
IC50 = 800 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0909765
 Compound Info 
1-(3,5-dichlorophenyl)-2-(perchlorocyclopenta-2,4-dien-1-ylidene)hydrazine
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C11H4Cl6N2
  1
1
IC50 = 800 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0389218
 Compound Info 
(2,3,4,5-tetrachlorocyclopenta-2,4-dien-1-ylidene)hydrazine
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C5H2Cl4N2
  1
1
IC50 = 1300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0930486
 Compound Info 
1,1-Dimethyl-2-(perchlorocyclopenta-2,4-dien-1-ylidene)hydrazine
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C7H6Cl4N2
  1
1
IC50 = 1300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0862692
 Compound Info 
1-(tert-Butyl)-2-(perchlorocyclopenta-2,4-dien-1-ylidene)hydrazine
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C9H10Cl4N2
  1
1
IC50 > 5000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0903507
 Compound Info 
1-Cyclohexyl-2-(perchlorocyclopenta-2,4-dien-1-ylidene)hydrazine
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C11H12Cl4N2
  1
1
IC50 > 5000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Clinical Information about the Protein
Target 1 ( DEP domain-containing protein 6 (DEPTOR) )
Target Type Literature-reported Target